http://naosite.lb.nagasaki-u.ac.jp/dspace The DSpace digital repository system captures, stores, indexes, preserves, and distributes digital research material. Search the Channel search http://naosite.lb.nagasaki-u.ac.jp/dspace/simple-search http://hdl.handle.net/10069/23070 Title: The patulous eustachian tube complicated with amyotrophic lateral sclerosis: a video clip demonstration. <br/> <br/>Authors: Takasaki, Kenji; Kumagami, Hidetaka; Umeki, Hiroshi; Enatsu, Kaori; Takahashi, Haruo <br/> <br/>Issue Date: 2008-11 <br/> <br/>Citation: The Laryngoscope, 118(11), pp.2057-2058; 2008 <br/> <br/>Abstract: We report a 60-year-old case diagnosed as the amyotrophic lateral sclerosis with patulous eustachian tube (ET). To our knowledge, this is the first case report of the amyotrophic lateral sclerosis complicating patulous ET in the literature, demonstrating the movement of the tympanic membrane, the pharyngeal orifice of the ET and abnormal movement of the uvula because of paralysis of the soft palate on video. <br/> <br/>Description: In order to view the file "VideoClip 1-3", you will need the Adobe® Acrobat® Reader™ version 9 or later. http://hdl.handle.net/10069/23069 Title: Capacity building of local governmental and non-governmental organizations on environmental hygiene through a community-based training workshop program. <br/> <br/>Authors: Ohnishi, Mayumi; Nakamura, Keiko <br/> <br/>Issue Date: 2009-01 <br/> <br/>Citation: Journal of interprofessional care, 23(1), pp.4-15; 2009 <br/> <br/>Abstract: This study was performed to evaluate the feasibility of a joint community-based environmental hygiene program in partnership between local governmental and non-governmental organizations with participants from different professional backgrounds, including inspectors of environmental sanitation and community leaders in Lagos, Nigeria, because no suitable collaboration had been implemented in this area. Qualitative and quantitative evaluations were performed with regard to malaria prevention and community-based environmental hygiene training workshops in three local communities in Lagos, Nigeria. Qualitative evaluation revealed the importance of establishment of close partnerships between local governmental and non-governmental organizations, and possible community participation in the program for its success. A total of 36 participants completed pre- and follow-up assessment before and after the three-day training course. The mean pre-test score was 27.8 +/- 13.9 (mean +/- standard deviation), while that of the follow-up test was 57.1 +/- 17.8. This mean gain of 29.3 +/- 17.4 in the score represented a significant improvement (p < 0.001). The objective of the training workshop, i.e., to implement the community-based environmental hygiene program, was successfully achieved. The training workshop also established good relations between governmental and non-governmental organizations with different professional backgrounds, and demonstrated the potential for sustained collaboration. http://hdl.handle.net/10069/23068 Title: Three DNA Polymerases, Recruited by Different Mechanisms, Carry Out NER Repair Synthesis in Human Cells <br/> <br/>Authors: Ogi, Tomoo; Limsirichaikul, Siripan; Overmeer, René M.; Volker, Marcel; Takenaka, Katsuya; Cloney, Ross; Nakazawa, Yuka; Niimi, Atsuko; Miki, Yoshio; Jaspers, Nicolaas G. <br/> <br/>Issue Date: 2010-03-12 <br/> <br/>Citation: Molecular Cell, 37(5), pp.714-727; 2010 http://hdl.handle.net/10069/23067 Title: A semi-automated non-radioactive system for measuring recovery of RNA synthesis and unscheduled DNA synthesis using ethynyluracil derivatives. <br/> <br/>Authors: Nakazawa, Yuka; Yamashita, Shunichi; Lehmann, Alan R; Ogi, Tomoo <br/> <br/>Issue Date: 2010-02-17 <br/> <br/>Citation: DNA repair, Article in Press <br/> <br/>Abstract: Nucleotide excision repair (NER) removes the major UV-photolesions from cellular DNA. In humans, compromised NER activity is the cause of several photosensitive diseases, one of which is the skin-cancer predisposition disorder, xeroderma pigmentosum (XP). Two assays commonly used in measurement of NER activity are 'unscheduled DNA synthesis (UDS)', and 'recovery of RNA synthesis (RRS)', the latter being a specific measure of the transcription-coupled repair sub-pathway of NER. Both assays are key techniques for research in NER as well as in diagnoses of NER-related disorders. Until very recently, reliable methods for these assays involved measurements of incorporation of radio-labeled nucleosides. We have established non-radioactive procedures for determining UDS and RRS levels by incorporation of recently developed alkyne-conjugated nucleoside analogues, 5-ethynyl-2'-deoxyuridine (EdU) and 5-ethynyuridine (EU). EdU and EU are respectively used as alternatives for (3)H-thymidine in UDS and for (3)H-uridine in RRS. Based on these alkyne-nucleosides and an integrated image analyser, we have developed a semi-automated assay system for NER-activity. We demonstrate the utility of this system for NER-activity assessments of lymphoblastoid samples as well as primary fibroblasts. Potential use of the system for large-scale siRNA-screening for novel NER defects as well as for routine XP diagnosis are also considered. http://hdl.handle.net/10069/23066 Title: 顕微ラマン法によるステアリン酸ポリタイプのミクロ構造研究 <br/> <br/>Authors: 森下, 浩史; 小林, 雅通; 佐藤, 清隆 <br/> <br/>Issue Date: 1986-07-10 <br/> <br/>Citation: 日本結晶成長学会誌. 13(1), p. 29 ; 1986 http://hdl.handle.net/10069/23065 Title: CEL-I, an N-acetylgalactosamine (GalNAc)-specific C-type lectin, induces nitric oxide production in RAW264.7 mouse macrophage cell line. <br/> <br/>Authors: Yamanishi, Tomohiro; Hatakeyama, Tomomitsu; Yamaguchi, Kenichi; Oda, Tatsuya <br/> <br/>Issue Date: 2009-08 <br/> <br/>Citation: Journal of biochemistry, 146(2), pp.209-217; 2009 <br/> <br/>Abstract: We found that CEL-I, a GalNAc-specific C-type lectin isolated from the marine invertebrate Holothuroidea (Cucumaria echinata), induces inducible nitric oxide synthase (iNOS) expression and NO production in RAW264.7 cells. The NO production was inhibited by an iNOS inhibitor, L-NAME, but was not by a lipopolysaccharide (LPS) inhibitor, polymyxin B. In the presence of 0.1-M GalNAc, increased NO production by CEL-I-treated RAW264.7 cells was observed rather than the inhibition. Bovine serum albumin (BSA) significantly inhibited the CEL-I-induced NO production as well as the binding of FITC-labelled CEL-I on RAW264.7 cells. Three MAP kinase inhibitors (specific to extra-cellular regulated kinase, c-jun NH(2)-terminal kinase and p38 MAP kinase) inhibited CEL-I-induced NO production with different extents. Heat-treatment of CEL-I resulted in a decreased activity of CEL-I depending on the temperature. These results suggest that CEL-I induces NO production in RAW264.7 cells through the protein-cell interaction rather than the binding to the specific carbohydrate chains on the cell surface. http://hdl.handle.net/10069/23064 Title: Regeneration of Graft Livers and Limited Contribution of Extrahepatic Cells After Partial Liver Transplantation in Humans. <br/> <br/>Authors: Eguchi, Susumu; Takatsuki, Mitsuhisa; Yamanouchi, Kosho; Kamohara, Yukio; Tajima, Yoshitsugu; Kanematsu, Takashi <br/> <br/>Issue Date: 2010-03 <br/> <br/>Citation: Digestive diseases and sciences, 55(3), pp.820-825; 2010 <br/> <br/>Abstract: Background Liver regeneration is still not fully understood. Partial liver transplantation (LT) can provide the opportunity to investigate the mechanisms of liver regeneration, including the contribution of extrahepatic cells to liver regeneration. Methods Of 61 patients transplanted with partial liver graft between August 1997 and October 2006, 56 patients were studied, including 49 adults and 7 children. Sequential computed tomography volumetric analysis was performed for volume measurement, while proliferating cell nuclear antigen (PCNA) labeling index was investigated for liver cell proliferation in nonprotocol liver biopsy specimens. In addition, 15 male recipients who had female liver grafts were investigated in order to detect Y chromosomes as extrahepatic cells in nonprotocol liver biopsy specimens. Results Graft volume per standard liver volume was markedly increased after adult-to-adult living-donor (LD) LT. In pediatric transplants, there was no volume increase over time. PCNA labeling index was vigorous in adult-to-adult LDLT in the early period after LDLT. No Y chromosome was evident in hepatocytes from female-donor male-recipient grafts during or after liver regeneration. However, in the cases of failing grafts of this type, many Y-chromosome-positive cells were observed in the graft liver. The character of those cells was CD34(-), CK9(-), hepatocyte-specific antigen(-), and CD68(+/-). Conclusion In adult-to-adult LDLT, vigorous liver regeneration occurs in the graft liver, demonstrated by not only volumetric but cell kinetic analysis. Involvement of extrahepatic cells in normal liver regeneration seems limited. http://hdl.handle.net/10069/23063 Title: Evaluation of swallowing pressure in a patient with amyotrophic lateral sclerosis before and after cricopharyngeal myotomy using high-resolution manometry system. <br/> <br/>Authors: Takasaki, Kenji; Umeki, Hiroshi; Enatsu, Kaori; Kumagami, Hidetaka; Takahashi, Haruo <br/> <br/>Issue Date: 2010 <br/> <br/>Citation: Auris Nasus Larynx, Article in Press <br/> <br/>Abstract: BACKGROUND: This study aimed to evaluate the pharyngeal pressure of a patient with, amyotrophic lateral sclerosis (ALS) before and after cricopharyngeal myotomy by high-resolution manometry (HRM) system. METHODS: A 60-year-old man with ALS underwent cricopharyngeal myotomy for his intractable, aspiration. The swallowing pressure along the velopharynx and upper esophagus was measured using, the HRM 1 month before and 3 months after the surgery. RESULTS: Before cricopharyngeal myotomy, the maximum values of the resting UES pressure, the dry swallowing, pressures in the velopharyngeal muscle zone and in the UES zone were 89, 95, and 171mmHg, respectively. After surgery, the maximum values of both the resting pressure and dry swallowing, pressure in the UES zone remarkably decreased to 21 and 75mmHg, respectively. CONCLUSIONS: This is the first report showing the effect of cricopharyngeal myotomy by demonstrating, the difference in the swallowing pressure along the velopharynx and upper esophagus before and after, the surgery in an ALS patient using this HRM system. http://hdl.handle.net/10069/23062 Title: Utility of preoperative dynamic magnetic resonance imaging of the pancreas in diagnosing tumor-forming pancreatitis that mimics pancreatic cancer: report of a case. <br/> <br/>Authors: Kuroki, Tamotsu; Tajima, Yoshitsugu; Tsuneoka, Noritsugu; Adachi, Tomohiko; Kanematsu, Takashi <br/> <br/>Issue Date: 2010-01 <br/> <br/>Citation: Surgery today, 40(1), pp.76-78; 2010 <br/> <br/>Abstract: The differential diagnosis of pancreatic carcinoma and tumor-forming pancreatitis remains difficult, and this situation can cause serious problems because the management and prognosis of these two focal pancreatic masses are entirely different. We herein report a case of tumor-forming pancreatitis that mimics pancreatic carcinoma in an 80-year-old woman. Computed tomography showed a solid mass in the head of the pancreas, and endoscopic retrograde cholangiopancreatography showed a complete obstruction of the main pancreatic duct in the head of the pancreas. Dynamic contrastenhanced magnetic resonance imaging (MRI) demonstrated a time-signal intensity curve (TIC) with a slow rise to a peak (1 min after the administration of the contrast material), followed by a slow decline at the pancreatic mass, indicating a fibrotic pancreas. Under the diagnosis of tumor-forming pancreatitis, the patient underwent a segmental pancreatectomy instead of a pancreaticoduodenectomy. The histopathology of the pancreatic mass was chronic pancreatitis without malignancy. The pancreatic TIC obtained from dynamiccontrast MRI can be helpful to differentiate tumor-forming pancreatitis from pancreatic carcinoma and to avoid any unnecessary major pancreatic surgery. <br/> <br/>Description: The original publication is available at www.springerlink.com http://hdl.handle.net/10069/23061 Title: Chemical constituents of the leaves of rabbiteye blueberry (Vaccinium ashei) and characterisation of polymeric proanthocyanidins containing phenylpropanoid units and A-type linkages <br/> <br/>Authors: Matsuo, Yosuke; Fujita, Yusuke; Ohnishi, Sachiko; Tanaka, Takashi; Hirabaru, Hideaki; Kai, Takanori; Sakaida, Hiroshi; Nishizono, Shoko; Kouno, Isao <br/> <br/>Issue Date: 2010 <br/> <br/>Citation: Food Chemistry, Article in Press <br/> <br/>Abstract: Chemical constituents of the leaves of rabbiteye blueberry (Vaccinium ashei READE) were investigated in detail. The major phenolic components were caffeoyl quinic acids, flavonol glycosides, flavan-3-ols and proanthocyanidins. Catechins and proanthocyanidins having additional phenylpropanoid units, such as cinchonains, kandelins and mururins, characterised the polyphenols of this plant. Among them, vaccinin A, an isomer of mururin A, was found to be a new compound, and the structure was characterised by spectroscopic methods. The most abundant polyphenols (11.3% of freeze-dried leaves) were oligomeric proanthocyanidins. Thiol degradation with mercaptoethanol indicated that the polymer was constituted of (+)-catechin and (-)-epicatechin as the terminal units and (-)-epicatechin, procyanidin A-2, and cinchonains Ia and Ib as the extension units. Mass spectral analysis suggested the presence of at least dodecamers with A-type linkages and phenylpropanoid moieties. http://hdl.handle.net/10069/23060 Title: Spatial Distribution and Pyrethroid Susceptibility of Mosquito Larvae Collected from Catch Basins in Parks in Nagasaki City, Nagasaki, Japan <br/> <br/>Authors: Kawada, Hitoshi; Maekawa, Yoshihide; Abe, Mayumi; Ohashi, Kazunori; Ohba, Shin-ya; Takagi, Masahiro <br/> <br/>Issue Date: 2010-01 <br/> <br/>Citation: Japanese Journal of Infectious Diseases, 63(1), pp.19-24; 2010 <br/> <br/>Abstract: We investigated the spatial distribution and pyrethroid susceptibility of the mosquito larvae belonging to Aedes albopictus and Culex pipiens group in catch basins located in parks in Nagasaki city, Nagasaki, Japan. Among the 308 parks located in the central regions of the city, 194 were investigated. Cx. pipiens group larvae were collected from 31 sites; larvae of Ae. albopictus, from 34 sites. The Cx. pipiens group larvae were identified by PCR: 93.4% were found to belong to Cx. pipiens pallens, and 0.9%, to Cx. pipiens form molestus. A bioassay was performed by observing the knockdown of larvae during 30-min exposures to 0.4- and 0.1-ppm solutions of d-allethrin. High tolerance to d-allethrin (susceptibility index = 36) was observed in only 1 colony of Cx. pipiens pallens across 24 sites. On the other hand, Ae. albopictus showed high tolerance (susceptibility index > 30) in 8 of 22 sites; this indicated that Ae. albopictus populations tolerant to pyrethroids were spreading widely in Nagasaki city. The organized and massive larvicidal treatment of graveyard containers with DDT in the 1950s was thought to be one of the main causes for the development of pyrethroid resistance in Ae. albopictus. http://hdl.handle.net/10069/23059 Title: P-selectin glycoprotein ligand-1 contributes to wound healing predominantly as a p-selectin ligand and partly as an e-selectin ligand. <br/> <br/>Authors: Tomita, Hajime; Iwata, Yohei; Ogawa, Fumihide; Komura, Kazuhiro; Shimizu, Kazuhiro; Yoshizaki, Ayumi; Hara, Toshihide; Muroi, Eiji; Yanaba, Koichi; Bae, Sangjae; Takenaka, Motoi; Hasegawa, Minoru; Fujimoto, Manabu; Sato, Shinichi <br/> <br/>Issue Date: 2009-08 <br/> <br/>Citation: Journal of Investigative Dermatology (2009) 129, 2059-2067 <br/> <br/>Abstract: Cell adhesion molecules are critical to wound healing through leukocyte recruitment. Although P-selectin glycoprotein ligand-1 (PSGL-1) regulates leukocyte rolling by binding P-selectin, but also binding E- and L-selectins with lower affinity, little is known about a role of PSGL-1 in wound healing. To clarify a role of PSGL-1 and its interaction with E- and P-selectins in wound healing, we investigated cutaneous wound healing in PSGL-1-deficient (PSGL-1(-/-)) mice in comparison with E-selectin(-/-), P-selectin(-/-), and P-selectin(-/-) mice treated with an anti-E-selectin antibody. PSGL-1 deficiency inhibited early wound healing, which was accompanied by decreased inflammatory cell infiltration and growth factor expression. By contrast, E-selectin deficiency did not affect wound healing. In general, the inhibitory effect of PSGL-1 deficiency on wound healing was similar to that of P-selectin deficiency either alone or with E-selectin blockade. However, early granulation tissue formation, late angiogenesis, and early infiltration of neutrophils and macrophages in PSGL-1(-/-) mice were inhibited beyond the inhibition in P-selectin(-/-) mice, but to a similar level of inhibition in P-selectin(-/-) mice with E-selectin blockade. These results suggest that PSGL-1 contributes to wound healing predominantly as a P-selectin ligand and partly as an E-selectin ligand by mediating infiltration of inflammatory cells. <br/> <br/>Description: without figures http://hdl.handle.net/10069/23058 Title: Decreased levels of autoantibody against histone deacetylase 3 in patients with systemic sclerosis. <br/> <br/>Authors: Kuwatsuka, Yutaka; Ogawa, Fumihide; Iwata, Yohei; Komura, Kazuhiro; Muroi, Eiji; Hara, Toshihide; Takenaka, Motoi; Shimizu, Kazuhiro; Hasegawa, Minoru; Fujimoto, Manabu; Sato, Shinichi <br/> <br/>Issue Date: 2009-02 <br/> <br/>Citation: Autoimmunity, 42 (2) pp. 120-125:2009 <br/> <br/>Abstract: Systemic sclerosis (SSc) is characterized by immunological abnormalities, especially the production of autoantibodies against various cellular components. Treatment with histone deacetylase (HDAC) inhibitors prevents collagen accumulation in a mouse SSc model. Additionally, autoantibody against HDAC-3 is produced in colon cancer patients, while HDAC-1 and HDAC-2 do not elicit autoantibody response. To determine the presence and levels of antibodies (Abs) against HDAC-3 in SSc. Anti-HDAC-3 Ab was examined by enzyme-linked immunosorbent assay (ELISA) and immunoblotting using human recombinant HDAC-3. The HDAC-3 activity was evaluated by ELISA using the fluorimetric HDAC lysyl substrate that comprises an acetylated lysine side chain. Contrary to our hypothesis that autoimmune background in SSc induced the production of autoantibody against HDACs, IgG and IgM anti-HDAC-3 Ab levels in SSc patients were significantly lower than in normal controls (p < 0.0005 and 0.001, respectively). Furthermore, decreased levels of IgG anti-HDAC-3 Ab were specific to SSc, since IgG anti-HDAC-3 Ab levels in patients with dermatomyositis (DM) and those with systemic lupus erythematosus (SLE) were similar and slightly increased relative to normal controls, respectively. Immunoblotting analysis showed that anti-HDAC-3 Ab was detected in normal controls and patients with DM or SLE, while it was absent in SSc patients. The HDAC-3 activity was significantly inhibited by IgG isolated from sera of normal controls, whereas such inhibitory effect was not observed by IgG isolated from sera of SSc patients. These results indicate the lack of anti-HDAC-3 autoantibody in SSc patients, which is produced in healthy individuals as well as DM and SLE patients, suggesting that this autoantibody might function as protective Ab. <br/> <br/>Description: This is an electronic version of an article published in Free Radical Research, 42(11-12), 957-965: 2008 November. Free Radical Research is available online at: http://informahealthcare.com/doi/abs/10.1080/08916930802406300 http://hdl.handle.net/10069/23057 Title: A protein secretion system linked to bacteroidete gliding motility and pathogenesis. <br/> <br/>Authors: Sato, Keiko; Naito, Mariko; Yukitake, Hideharu; Hirakawa, Hideki; Shoji, Mikio; McBride, Mark J; Rhodes, Ryan G; Nakayama, Koji <br/> <br/>Issue Date: 2010-01-05 <br/> <br/>Citation: PNAS, 107(1), pp.276-281; 2010 <br/> <br/>Abstract: Porphyromonas gingivalis secretes strong proteases called gingipains that are implicated in periodontal pathogenesis. Protein secretion systems common to other Gram-negative bacteria are lacking in P. gingivalis, but several proteins, including PorT, have been linked to gingipain secretion. Comparative genome analysis and genetic experiments revealed 11 additional proteins involved in gingipain secretion. Six of these (PorK, PorL, PorM, PorN, PorW, and Sov) were similar in sequence to Flavobacterium johnsoniae gliding motility proteins, and two others (PorX and PorY) were putative two-component system regulatory proteins. Real-time RT-PCR analysis revealed that porK, porL, porM, porN, porP, porT, and sov were down-regulated in P. gingivalis porX and porY mutants. Disruption of the F. johnsoniae porT ortholog resulted in defects in motility, chitinase secretion, and translocation of a gliding motility protein, SprB adhesin, to the cell surface, providing a link between a unique protein translocation system and a motility apparatus in members of the Bacteroidetes phylum. http://hdl.handle.net/10069/23056 Title: Efficacy of ME1036 against meticillin-resistant Staphylococcus aureus and vancomycin-insensitive S. aureus in a model of haematogenous pulmonary infection. <br/> <br/>Authors: Yanagihara, Katsunori; Ohnishi, Yuriko; Morinaga, Yoshitomo; Nakamura, Shigeki; Kurihara, Shintaro; Seki, Masafumi; Izumikawa, Koichi; Kakeya, Hiroshi; Yamamoto, Yoshihiro; Yamada, Yasuaki; Kohno, Shigeru; Kamihira, Shimeru <br/> <br/>Issue Date: 2008-11 <br/> <br/>Citation: International journal of antimicrobial agents, 32(5), pp.401-404; 2008 <br/> <br/>Abstract: ME1036, a novel parenteral carbapenem, was developed for the treatment of meticillin-resistant Staphylococcus aureus (MRSA) and vancomycin-intermediate S. aureus (VISA). A model of haematogenous pulmonary infection was induced in mice by tail vein injection of MRSA strain NUMR101 or VISA Mu50 enmeshed in agar beads. After 24h of infection, mice were treated twice daily for 7 days with 200mg/kg/day vancomycin (VCM) or ME1036. Mice infected with VISA were also pre-treated with cyclophosphamide to induce an immunocompromised state. The number of viable bacteria in the lungs was counted 12h after the final drug treatment. VCM decreased the number of viable MRSA in the lungs in comparison with the control, although the difference was not significant (mean+/-standard error of the mean log(10) colony-forming units (CFU)/lung=6.876+/-0.54 vs. 8.25+/-0.41, respectively). In contrast, treatment with ME1036 resulted in a significant decrease in the number of viable MRSA (log(10)CFU/lung=2.69+/-0.44 (n=6); P<0.0001) compared with both the VCM-treated and control mice. In the VISA-infected mice, ME1036 significantly reduced the number of viable bacteria compared with VCM and control (log(10)CFU/lung=3.65+/-0.68 for ME1036 vs. 5.71+/-0.75 for VCM (P<0.05) and 7.07+/-0.45 for control (P<0.001)). ME1036 produced >3 log(10) reduction versus control against both MRSA strains (>5 log for the VCM-susceptible strain and 3.4 log for the VISA), whereas VCM produced <1.3 log for both strains. http://hdl.handle.net/10069/23055 Title: A 52-year-old male with fever and rapidly progressive dyspnea. <br/> <br/>Authors: Nakamura, Shigeki; Yanagihara, Katsunori; Izumikawa, Koichi; Seki, Masafumi; Kakeya, Hiroshi; Yamamoto, Yoshihiro; Kohno, Shigeru <br/> <br/>Issue Date: 2008-11 <br/> <br/>Citation: Respiration, 76(4), pp.454-457; 2008 http://hdl.handle.net/10069/23054 Title: Multicentric occurrence and spread of hepatocellular carcinoma in whole explanted end-stage liver. <br/> <br/>Authors: Hidaka, Masaaki; Eguchi, Susumu; Okudaira, Sadayuki; Takatsuki, Mitsuhisa; Tokai, Hirotaka; Soyama, Akihiko; Nagayoshi, Shigeki; Mochizuki, Satoshi; Hamasaki, Koji; Tajima, Yoshitsugu; Kanematsu, Takashi <br/> <br/>Issue Date: 2009-02 <br/> <br/>Citation: Hepatology research, 39(2), pp.143-148; 2009 <br/> <br/>Abstract: Aim: Hepatocellular carcinoma (HCC) arising from the end stages of liver cirrhosis is a fair indication for liver transplantation (LT). To pathologically investigate the multicentric occurrence of relatively early staged HCC in cirrhosis, we studied whole explanted livers. Methods: Fourteen explanted livers from patients undergoing living donor LT (LDLT) were examined. The stage of the HCCs was judged to be within the Milan criteria (M-C; a single HCC less than 5 cm or three HCCs less than 3 cm). Histological examination was performed using serially sectioned specimens 5-7 mm in width. Characterization of preoperatively detectable and undetectable lesions was also performed. Results: In nine patients (64.3%), a total of 34 nodules were found after whole liver histological examination (WLHE). In five patients (31%), the results exceeded the M-C. The characteristics of undetectable HCCs included a minute (median size 6 mm), well-differentiated appearance (80%), with indistinct margins (85.3%) and without vascular invasion (94%). There was no recurrence in any patients at the time of follow up (median follow-up period, 30.1 months). Conclusion: A multicentric occurrence of HCCs was demonstrated in cirrhotic livers with HCCs within the M-C. Undetectable HCCs in cirrhotic livers may have no impact on recurrence after LT. http://hdl.handle.net/10069/23053 Title: コンクリート充填鋼管アーチ橋(新西海橋主橋部)の動的特性と施工に関する研究 <br/> <br/>Authors: 吉村, 光弘 <br/> <br/>Issue Date: 2007-03-20 <br/> <br/>Description: 長崎大学学位論文 学位記番号:博(生)甲第110号 学位授与年月日:平成19年3月20日 http://hdl.handle.net/10069/23052 Title: ナミハダニの非休眠性が有利になる条件 : モデルによる解析(第 20 回ダニ類研究会大会講演要旨) <br/> <br/>Authors: 高藤, 晃雄; 津田, 良夫 <br/> <br/>Issue Date: 1992-05-25 <br/> <br/>Citation: 日本ダニ学会誌, 1(1), pp. 64-65; 1992 http://hdl.handle.net/10069/23051 Title: 長崎県の二つの離島の恙虫病媒介種の推定(第 1 回日本ダニ学会大会講演要旨) <br/> <br/>Authors: 鈴木, 博; 麻生, 卓郎 <br/> <br/>Issue Date: 1993-05-25 <br/> <br/>Citation: 日本ダニ学会誌, 2(1), pp. 38-39; 1993 http://hdl.handle.net/10069/23050 Title: 雲仙・普賢岳に於ける噴火前と噴火後 4 年目の恙虫と野鼠類の比較(第 3 回日本ダニ学会大会講演要旨) <br/> <br/>Authors: 鈴木, 博 <br/> <br/>Issue Date: 1995-05-25 <br/> <br/>Citation: 日本ダニ学会誌, 4(1), pp. 34-34; 1995 http://hdl.handle.net/10069/23049 Title: 鹿児島県大隅で採集された Doloisia sp. について(第 4 回日本ダニ学会大会講演要旨) <br/> <br/>Authors: 鈴木, 博; 内川, 公人; 野田, 伸一; 山本, 進 <br/> <br/>Issue Date: 1996-05-25 <br/> <br/>Citation: 日本ダニ学会誌, 5(1), pp. 42-42; 1996 http://hdl.handle.net/10069/23048 Title: メカライフの世界展を終えて(九州学生会)(学生だより) <br/> <br/>Authors: 久保, 雅和 <br/> <br/>Issue Date: 2004-03-05 <br/> <br/>Citation: 日本機械学會誌 , vol.107, pp. 186-187; 2004 http://hdl.handle.net/10069/23047 Title: レーザ2焦点流速粒径測定器の開発 <br/> <br/>Authors: 植木, 弘信; 石田, 正弘 <br/> <br/>Issue Date: 1993-09-05 <br/> <br/>Citation: 日本機械学會誌 , vol.96, p. 850; 1993 http://hdl.handle.net/10069/23046 Title: リモートセンシングと暮らし <br/> <br/>Authors: 後藤, 恵之輔 <br/> <br/>Issue Date: 1989-03-05 <br/> <br/>Citation: 日本機械学會誌 , vol.92, pp. 185-191; 1989 http://hdl.handle.net/10069/23045 Title: 超大面積アモルファスシリコン薄膜の形成 <br/> <br/>Authors: 藤山, 寛 <br/> <br/>Issue Date: 1988-10-05 <br/> <br/>Citation: 日本機械学會誌. vol. 91, p. 1111; 1988 http://hdl.handle.net/10069/23044 Title: 両振りねじりをうける7:3黄銅の疲れ被害について <br/> <br/>Authors: 真武, 友一 <br/> <br/>Issue Date: 1967-09-05 <br/> <br/>Citation: 日本機械学會誌. vol. 70, p. 1377; 1967 http://hdl.handle.net/10069/23043 Title: 両振り曲げをうける7:3黄銅の疲れ被害について <br/> <br/>Authors: 真武, 友一 <br/> <br/>Issue Date: 1967-12-05 <br/> <br/>Citation: 日本機械学會誌 , vol.70, pp. 1848-1849; 1967 http://hdl.handle.net/10069/23042 Title: 組合せ応力をうける 7:3 黄銅の疲れ被害について <br/> <br/>Authors: 真武, 友一 <br/> <br/>Issue Date: 1968-03-05 <br/> <br/>Citation: 日本機械学會誌. vol. 71, p. 423; 1968 http://hdl.handle.net/10069/23041 Title: アブレイシブ磨耗に及ぼす粉体粒径の影響 <br/> <br/>Authors: 平野, 冨士夫; 浦, 晟 <br/> <br/>Issue Date: 1972-01-00 <br/> <br/>Citation: 日本機械学會誌. vol. 75, p. 152; 1972