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Facile Discrimination of Aldose Enantiomers by Reversed-Phase HPLC

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Title: Facile Discrimination of Aldose Enantiomers by Reversed-Phase HPLC
Authors: Tanaka, Takashi / Nakashima, Tatsuya / Ueda, Toshihisa / Tomii, Kenji / Kouno, Isao
Issue Date: Jun-2007
Publisher: The Pharmaceutical Society of Japan
Citation: Chemical & Pharmaceutical Bulletin v.55(6) p.899-901, 2007
Abstract: One-pot reactions of aldoses with L-cysteine methyl ester and o-tolyl isothiocyanate yielded methyl 2-(polyhydroxyalkyl)-3-(o-tolylthiocarbamoyl)-thiazolidine-4(R)-carboxylates. Direct HPLC analysis of the reaction mixture and UV detection at 250 nm discriminated D- and L-enantiomers of aldoses. The reaction was applied to the determination of absolute configuration the sugar residues of an aroma precursor.
Keywords: aldose / absolute configuration / HPLC / cysteine / isothiocyanate
URI: http://hdl.handle.net/10069/14910
ISSN: 00092363
DOI: 10.1248/cpb.55.899
PubMed ID: 17541189
Relational Links: http://dx.doi.org/10.1248/cpb.55.899
Type: Journal Article
Text Version: publisher
Appears in Collections:Articles in academic journal

Citable URI : http://hdl.handle.net/10069/14910

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