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Effect of Anesthetics on the Pituitary-Adrenocortical System of the Rat

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Title: Effect of Anesthetics on the Pituitary-Adrenocortical System of the Rat
Authors: Mitamura, Takaaki
Authors (alternative): 三田村, 孝朗
Issue Date: 25-Apr-1960
Citation: Acta medica Nagasakiensia. 1960, 5(1), p.58-62
Abstract: The effect of various anesthetics on the pituitary-adrenocortical system was studied in rats, using the depletion of adrenal ascorbic acid as an index of adrenal-cortical activity. The anesthetics applied were Evipan-sodium, ether, urethane, morphine and sodium pentobarbital. Anesthetization with ether, urethane and morphine (10 mg per 100 g body weight) induced a remarkable adrenal ascorbic acid depletion in rats. Ascorbic acid depletion in the adrenal after application of Evipan-sodium or morphine (2 mg per 100 g body weight) was mild, and no definite change in adrenal ascorbic acid concentration was produced by sodium pentobarbital anesthesia. In hypophysectomized rats anesthetization did not produce adrenal ascorbic acid depletion.
URI: http://hdl.handle.net/10069/15430
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 5, No. 1

Citable URI : http://hdl.handle.net/10069/15430

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