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Effect of Anesthetics on Phosphate (32P) Metabolism of the Rat Brain


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Title: Effect of Anesthetics on Phosphate (32P) Metabolism of the Rat Brain
Authors: Takenaka, Fumio / Ide, Takeshi
Authors (alternative): 岳中, 典男 / 井出, 大
Issue Date: 25-Oct-1960
Citation: Acta medica Nagasakiensia. 1960, 5(2-3), p.76-80
Abstract: The effect of chlorpromazine (Chp), ether, hexobarbital (evipal) and urethan on the content and turnover rate of phosphate compounds in rat brain tissue was investigated. 32P was taken up into various phosphate fractions in the following order of decreasing rate: ATP, creatine phosphate (CP), nucleoprotein (NP) and phospholipid (LP). ATP concentration was increased and the turnover rate of the fraction was diminished by Chp with evipal (Chp-evipal) and Chp with urethan (Chp-urethan) anesthesia. CP concentration was not appreciably changed but its turnover rate was decreased except for Chp with ether (Chp-ether) anesthesia in which a reduction of CP and acceleration of its turnover rate was noted. These findings suggest that the utilization of high energy phosphate esters is inhibited by Chp-evipal and Chp-urethan but not by Chp-ether. The incorporation of 32P into LP and NP was significantly decreased after 2-hour anesthesia, while it was rather increased within 30 minutes particularly with Chp-ether anesthesia. A different mode of action of Chp-ether on phosphate metabolism of the brain is suspected when compared with that of Chp-evipal as well as Chp-urethan.
URI: http://hdl.handle.net/10069/15433
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 5, No. 2-3

Citable URI : http://hdl.handle.net/10069/15433

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