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Effect of Tetramethylammonium on the Adrenal Medullary Secretion in the Dog


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Title: Effect of Tetramethylammonium on the Adrenal Medullary Secretion in the Dog
Authors: Goto, Satoru
Authors (alternative): 後藤, 覚
Issue Date: 25-Oct-1960
Citation: Acta medica Nagasakiensia. 1960, 5(2-3), p.108-115
Abstract: In dogs anesthetized with Evipan-sodium, the adrenal venous blood was collected by the lumbar route method and was estimated chemically for adrenaline. Tetramethylammonium (TMA) injected in a dose of 1.0 mg per kg induced invariably the augmentation of adrenaline secretion of the adrenal gland with intact innervation as well as of the acutely denervated one. From the former the maximal secretion rate was measured on the average as 1.6 μg per kg per min. and from the latter as 1.1 μg. It is concluded that TMA induces an augmentation of adrenaline secretion chiefly by acting directly on the adrenal medulla. Adrenaline-secretory action of TMA was found to be about three times as strong as that of acetylcholine (ACh). Repeated TMA injections at five-minute intervals were made. The adrenaline secretion rate increased after each injection. Continuous infusion of TMA produced at first an increase in adrenaline secretion. During infusion the secretion rate decreased gradually.
URI: http://hdl.handle.net/10069/15437
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 5, No. 2-3

Citable URI : http://hdl.handle.net/10069/15437

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