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Comparative Studies on Coronary Dilators


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Title: Comparative Studies on Coronary Dilators
Authors: Miyake, Nobuaki
Authors (alternative): 三宅, 信昭
Issue Date: 25-Sep-1961
Citation: Acta medica Nagasakiensia. 1961, 6(1-2), p.13-19
Abstract: The comparative potency of coronary dilators was investigated by using a rolling circular manometer system in the isolated perfused cat's heart. The doses capable of producing a 50 per cent increase in coronary blood flow were compared. The values in μM for caffeine, Diuretin, Aminophylline, hydroxyethyl-theophylline, dihydroxypropyl-theophylline, adenosine, papaverine, and Persantin were found to be 26, 28, 5, 50, 60, 0.0018, 3, and 2.5, respectively. The duration of action was evaluated by the doses required to maintain a 2-minute period of increased coronary flow. The values in μM in the same order of the compounds mentioned above were represented as 52, 28, 5, 25, 5, 0.006, 5, and 0.13, respectively. The results derived from the experiments using coronary vascular strips suggest that a possible site of action of Persantin is located in the vascular smooth muscle itself.
URI: http://hdl.handle.net/10069/15452
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 6, No. 1-2

Citable URI : http://hdl.handle.net/10069/15452

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