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Inhibition of Atrial. Anaphylaxis by Corticosteroids


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Title: Inhibition of Atrial. Anaphylaxis by Corticosteroids
Authors: Kajiyama, Tadahiko
Authors (alternative): 梶山, 忠彦
Issue Date: 25-Mar-1962
Citation: Acta medica Nagasakiensia. 1962, 6(3-4), p.74-82
Abstract: Anaphylactic reaction in the heart isolated from sensitized guinea pigs has been studied extensively by NAKAZAWA and his collaborators using isolated atria, whole hearts or ventricle strips. The anaphylactic reaction in those preparations are found generally as an augmentation of contractile force and acceleration of rate. In the present paper, an attempt was made to evaluate the inhibiting effect of corticosteroids and their analogs to the anaphylactic reaction in isolated atria because the reaction was considered semiquantitative. As the results, corticosteroids administered in vitro showed no preventive effect on the anaphylactic reaction of the atria. Glucocorticoids administered in the sensitized animal prior to preparation showed inhibition of augmentation of contractile force in the anaphylactic reaction, but no inhibition was observed in its accelerating effect. Desoxycorticosterone given in vivo was found to increase the amplitude enhancing effect in atria anaphylaxis and also to enhance, histamine, serotonin and adrenaline action.
URI: http://hdl.handle.net/10069/15460
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 6, No. 3-4

Citable URI : http://hdl.handle.net/10069/15460

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