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Effect of Estrone- and Estriol-3-methyl Ether on Progesterone in Decidual Development

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Title: Effect of Estrone- and Estriol-3-methyl Ether on Progesterone in Decidual Development
Authors: Yamashita, Kazukuni
Authors (alternative): 山下, 一邦
Issue Date: 25-Mar-1962
Citation: Acta medica Nagasakiensia. 1962, 6(3-4), p.100-103
Abstract: The ovariectomized rats were used. After estrogen-priming for six days, a thread was placed into the lumen of one uterine cornu, the contralateral untreated cornu served as a control. The animals were then injected with progesterone and test compounds for five days. Total of 10 mg of progesterone effected- a 336% increase over the contralateral untreated cornu. However, when various doses of estrogen-3-methyl ether were given with 10 mg of progesterone, the effect on decidual development was significantly weaker than that due to progesterone alone. In a dose of 1.0 mg, percent inhibition to the effect of progesterone was 97 by estrone-3-methyl ether and 64 by estriol-3-methyl ether. The results indicate that estrone- and estriol-3-methyl ether are capable of inhibiting the decidual response to progesterone.
URI: http://hdl.handle.net/10069/15463
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 6, No. 3-4

Citable URI : http://hdl.handle.net/10069/15463

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