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Changes in the Transmembrane Action Potential's Pattern of the Specialized Fiber in Guinea Pig Atria During Anaphylaxis in Vitro


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Title: Changes in the Transmembrane Action Potential's Pattern of the Specialized Fiber in Guinea Pig Atria During Anaphylaxis in Vitro
Authors: Kido, Masayuki
Authors (alternative): 木戸, 正之
Issue Date: 25-Oct-1964
Citation: Acta medica Nagasakiensia. 1964, 9(1-2), p.29-39
Abstract: Although it was reported from our laboratory that the duration in the transmembrane A. P. of the proper atrial fiber is prolonged by anaphylaxis, no study on the changes in the action potential of the specialized fiber have been reported. So the present study was attempted to search changes in the membrane function of the pacemaker, using the ultramicroelectrode technique. Anaphylaxis causes an acceleration of the rhythm with the increased slope of the prepotential and without any changes in its height, so the beat acceleration may depend on the activities of ionic movement during diastole but not on the membrane excitability. And no specific change was observed in anaphylaxis in the high K-media. The A. P. pattern of the specialized fiber in anaphylaxis apparently differs from that caused by histamine, acetylcholine and serotonin, while it is very similar to adrenaline. But adequate dose of DCI gave no influence on anaphylactic manifestations. A possible role of these drugs on anaphylactic reactions may be excluded through changes in the pattern of the action potential and the attitude of anaphylaxis against DCI.
URI: http://hdl.handle.net/10069/15485
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 9, No. 1-2

Citable URI : http://hdl.handle.net/10069/15485

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