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The Influence of Mersalyl and some Sulfhydryl Group Reagents on the Pacemaker Action Potential and the Contraction in Isolated Guinea Pig Atria.


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タイトル: The Influence of Mersalyl and some Sulfhydryl Group Reagents on the Pacemaker Action Potential and the Contraction in Isolated Guinea Pig Atria.
著者: Tani, Michio
著者(別表記) : 谷, 美智士
発行日: 1968年 3月25日
引用: Acta medica Nagasakiensia. 1968, 12(3-4), p.99-111
抄録: In order to analyze the cause of a cardiotoxic action of mersalyl, its direct effects of transmembrane action potential in cardiac pacemaker cells and on contractility of the atrial muscle fibers were investigated in isolated guinea pig hearts. The effect was compared with those of sod. arsenite, iodoacetamide, N-ethylmaleimide and iodosobenzene acetate. All of these SH reagents caused a shortening of the duration and a reduction of the propagated action potential. The former change is considered as a cause of the rhythm accerelating effect of these reagents, and the latter as a cause of arrhythmia. The reagents act on the contractility different ways, while iodoacetamide and sod. arsenite having a marked depolarizing charactor cause the contracture.
URI: http://hdl.handle.net/10069/15530
ISSN: 00016055
資料タイプ: Departmental Bulletin Paper
原稿種類: publisher
出現コレクション:Volume 12, No. 3-4

引用URI : http://hdl.handle.net/10069/15530

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