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The Influence of Mersalyl and some Sulfhydryl Group Reagents on the Pacemaker Action Potential and the Contraction in Isolated Guinea Pig Atria.


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Title: The Influence of Mersalyl and some Sulfhydryl Group Reagents on the Pacemaker Action Potential and the Contraction in Isolated Guinea Pig Atria.
Authors: Tani, Michio
Authors (alternative): 谷, 美智士
Issue Date: 25-Mar-1968
Citation: Acta medica Nagasakiensia. 1968, 12(3-4), p.99-111
Abstract: In order to analyze the cause of a cardiotoxic action of mersalyl, its direct effects of transmembrane action potential in cardiac pacemaker cells and on contractility of the atrial muscle fibers were investigated in isolated guinea pig hearts. The effect was compared with those of sod. arsenite, iodoacetamide, N-ethylmaleimide and iodosobenzene acetate. All of these SH reagents caused a shortening of the duration and a reduction of the propagated action potential. The former change is considered as a cause of the rhythm accerelating effect of these reagents, and the latter as a cause of arrhythmia. The reagents act on the contractility different ways, while iodoacetamide and sod. arsenite having a marked depolarizing charactor cause the contracture.
URI: http://hdl.handle.net/10069/15530
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 12, No. 3-4

Citable URI : http://hdl.handle.net/10069/15530

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