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Amino Acid Sequences of Tryptic Peptides,αT9, αT10, and αT11 from . the α-Polypeptide Chain in Macaca mulatto, Monkey Hemoglobin


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Title: Amino Acid Sequences of Tryptic Peptides,αT9, αT10, and αT11 from . the α-Polypeptide Chain in Macaca mulatto, Monkey Hemoglobin
Authors: Miyauchi, Takao
Authors (alternative): 宮内, 孝夫
Issue Date: 25-Oct-1968
Citation: Acta medica Nagasakiensia. 1968, 13(1-2), p.18-29
Abstract: A partial amino acid sequence of the α-polypeptide chain in hemoglobin from macaca mulatta monkey was determined and compared with the known sequence of the corresponding part of human hemoglobin. Two differences were discovered between them. The α-polypeptide chain of macaca mulatta monkey hemoglobin was hydrolyzed with trypsin. Three tryptic peptides, α.T9, αT10, and αT11 were the subjects of this experiment. αT9 was further hydrolyzed with pepsin and then the amino acld sequence of αT9 was determined by arranging partial sequences of those peptic peptides which were determined by PTC and DNP methods. The sequences of αT10 and αT11 were directly determined by PTC and DNP methods. The comparison of the results thus obtained with the known sequence of human hemoglobin showed that there were two differences only in αT9. Namely, the seventh and the tenth amino acid residues from the N-terminus were respectively asparagine and alanine in human hemoglobin, but leucine and glycine in macaca mulatta monkey hemoglobin.
URI: http://hdl.handle.net/10069/15535
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 13, No. 1-2

Citable URI : http://hdl.handle.net/10069/15535

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