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Studies on the Elimination of Catecholamine in the Dog's Liver in Vivo after the Administration of Adrenaline and Noradrenaline


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Title: Studies on the Elimination of Catecholamine in the Dog's Liver in Vivo after the Administration of Adrenaline and Noradrenaline
Authors: Noritomi, Satoru
Authors (alternative): 乗富, 智
Issue Date: 25-Oct-1968
Citation: Acta medica Nagasakiensia. 1968, 13(1-2), p.94-113
Abstract: In dogs anesthetized with sodium pentobarbital, adrenaline and noradrenaline in the portal and hepatic vein were estimated by using a fluorimetric method after the administration of mixed each 100μg/kg of adrenaline and noradrenaline. Four groups of experiments were performed in the present study as follow; (1) Intact dogs (2) Carbon tetrachloride intoxicated dogs (CCl4-dogs) (3) Chloroform intoxicated dogs (CHCl3-dogs) (4) Dogs with obstructive jaundice due to common bile duct ligation (Jaundice dogs) In intact dogs, the reduction rate of catecholamine in the liver 1 minute after the administration of adrenaline and noradrenaline was over 70.1% for adrenaline and 56.1% for noradrenaline. Then the reduction rate of adrenaline was higher than that of noradrenaline. The content of catecholamine was markedly reduced at 3 minutes, and the reduction rate was less at 3 minutes than at 1 minute. In dogs with severe damaged liver such as CCl4-dogs and CHCl3-dogs, the reduction rate of catecholamine in the liver was lowered markedly about 10 to 30%, and a highly significant difference was found between this group and intact group. In jaundice dogs with the moderate damaged liver, the figure was between the above two groups. Levels of S-GOT and S-GPT were inversely proportional to the reduction rate of adrenaline and noradrenaline in the liver. In intact dogs the glucose from the liver began to release between 1 and 3 minutes after the catecholamine infusion and showed as peak at 7 minutes. On the other hand, in CCl4-dogs and CHCl3-dogs the glucose output from the liver was not occured. In jaundice dogs the glucose output from the liver was found, but less than in intact dogs. It is concluded that the liver would reduce a large amount of adrenaline and noradrenaline and the reduction rate would vary in proportion to the degree of damage to the liver.
URI: http://hdl.handle.net/10069/15540
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 13, No. 1-2

Citable URI : http://hdl.handle.net/10069/15540

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