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Ultrastructural Study of Secretory Granules in the Juxtaglomerular Cells -Particularly on Formation and Extrusion-


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Title: Ultrastructural Study of Secretory Granules in the Juxtaglomerular Cells -Particularly on Formation and Extrusion-
Authors: Tsuda, Nobuo
Authors (alternative): 津田, 暢夫
Issue Date: 25-Mar-1969
Citation: Acta medica Nagasakiensia. 1969, 13(3-4), p.140-155
Abstract: The secretory granules in the juxtaglomerular cells which are believed to be renin or renin-like substance are of experimental and clinical interest since they are related to hypertension and Na balance. Electron microscopic observations were made with rats on the mechanism of formation and extrusion of secretory granules upon giving stimulation to the juxtaglomerular cells by means of restricted salt diet and administration of diuretics. As to the formation of granules, rough-surfaced endoplasmic reticulum developed into Golgi apparatus, immature granules and finally mature granules. At least, one of the extrusion types was diacrine mechanism since there was observed "fading" of granule content while the limit membrane was maintained. In view of the fact that extrusion by diacrine mechanism is generally of the substance of low molecular weight, it is presumed that the content of JG cell might be prmitive renin of relatively low molecular weight or might possibly include some substance other than renin.
URI: http://hdl.handle.net/10069/15543
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 13, No. 3-4

Citable URI : http://hdl.handle.net/10069/15543

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