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PULMONARY SURFACE TENSION An Approach to the Evaluation of Surface Tension

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タイトル: PULMONARY SURFACE TENSION An Approach to the Evaluation of Surface Tension
著者: Okamoto, Sumitada
著者(別表記) : 岡本, 純忠
発行日: 1970年 3月25日
引用: Acta medica Nagasakiensia. 1970, 14(3-4), p.87-97
抄録: A study was carried out on the significance of surface tension values of lung washing extracts obtained from dogs consisting of fasted and linoleate-fed groups. The mean maximal surface tension of the latter was lower than that of the former (P<0.05). The mean minimal surface tension of the latter was higher than the former (not significant). The frequency polygon of the minimal surface tensions was divided into two portions for the linoleate-fed group.. On the other hand, twofold serial dilution of washing extracts was performed and then tension-concentration diagram was drawn with surface tension on its ordinate and phospholipid concentration of the extract on its abscissa. The tension-concentration diagram showed that the surface tension decreased to some level as the concentration of phospholipid increased, but no further lowering of the tension was observed regardless of increased concentration. Judging from the tension-concentration diagram, it was possible to conceive critical micelle concentration (c.m.c.) in lung washing extracts. There was no significant difference in the pattern between the fasted group and the linoleate-fed group, partly because of the relatively wide range of c.m.c. Phosphatidyl-choline (Ph-C) was a major component of the washing extract. Ph-C fractions were also isolated from soy-bean lecithin, serum and lung tissues, and the respective values of their minimal surface tensions were 32.1, 28.2 and 28.8 dynes/cm at c.m.c. (0.3 γ of phosphorus). The minimal surface tension of Ph-C isolated from washing extract of the fasted dog attained 3.0 dynes/cm at c.m.c.(15 γ of phosphorus). Ph-C of the linoleate-fed dog demonstrating higher minimal tension value (11.7 dynes/cm) in the crude washing showed the value of 12.6 dynes/cm at the same concentration level(15 γ of phosphorus). It was concluded from the data that tension-concentration diagram is important for the precise evaluation of surface tension values of lung washing extracts.
URI: http://hdl.handle.net/10069/15557
ISSN: 00016055
資料タイプ: Departmental Bulletin Paper
原稿種類: publisher
出現コレクション:Volume 14, No. 3-4

引用URI : http://hdl.handle.net/10069/15557



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