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Blockade of Hypothalamo-Hypophyseal-Adrenocortical Mechanism Caused by Dexamethasone


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タイトル: Blockade of Hypothalamo-Hypophyseal-Adrenocortical Mechanism Caused by Dexamethasone
著者: Nakasone, Keishun / Shimizu, Takeshi
著者(別表記) : 仲宗根, 恵俊 / 清水, 武
発行日: 1971年 3月25日
引用: Acta medica Nagasakiensia. 1971, 15(1-4), p.49-57
抄録: An effort has been made to elucidate the effect of dexamethasone on adrenocortical secretory function in dogs. The secretory activity was determined by measuring 11-hydroxycorticosteroids (11-OHCS) in adrenal venous blood. In dogs under sodium pentobarbital anesthesia (25 mg/kg, injected i. v.) , dexamethasone-21-phosphate was administered subcutaneously in doses of 50-200 μg/kg before the stress. This pretreatment inhibited largely the adrenocortical stimulation resulting from the surgical stress or X-irradiation of the adrenal. The most effective suppression was obtained with a single injection of 100 μg/kg. Intravenous injections of 5-500mU/kg of ACTH to dogs pretreated with 100 μg/kg of dexamethasone responded by showing definite increases in adrenal 11-OHCS secretion, the degree of the increase depended on the dosage administered . In adrenocortical response to exogenous ACTH, double treatments with 100 μg/kg of dexamethasone resulted in lesser secretion rates of 11-OHCS than a single treatment. These findings would suggest the adrenal cortex as one of the sites of inhibition.
URI: http://hdl.handle.net/10069/15563
ISSN: 00016055
資料タイプ: Departmental Bulletin Paper
原稿種類: publisher
出現コレクション:Volume 15, No. 1-4

引用URI : http://hdl.handle.net/10069/15563

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