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Blockade of Hypothalamo-Hypophyseal-Adrenocortical Mechanism Caused by Dexamethasone

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Title: Blockade of Hypothalamo-Hypophyseal-Adrenocortical Mechanism Caused by Dexamethasone
Authors: Nakasone, Keishun / Shimizu, Takeshi
Authors (alternative): 仲宗根, 恵俊 / 清水, 武
Issue Date: 25-Mar-1971
Citation: Acta medica Nagasakiensia. 1971, 15(1-4), p.49-57
Abstract: An effort has been made to elucidate the effect of dexamethasone on adrenocortical secretory function in dogs. The secretory activity was determined by measuring 11-hydroxycorticosteroids (11-OHCS) in adrenal venous blood. In dogs under sodium pentobarbital anesthesia (25 mg/kg, injected i. v.) , dexamethasone-21-phosphate was administered subcutaneously in doses of 50-200 μg/kg before the stress. This pretreatment inhibited largely the adrenocortical stimulation resulting from the surgical stress or X-irradiation of the adrenal. The most effective suppression was obtained with a single injection of 100 μg/kg. Intravenous injections of 5-500mU/kg of ACTH to dogs pretreated with 100 μg/kg of dexamethasone responded by showing definite increases in adrenal 11-OHCS secretion, the degree of the increase depended on the dosage administered . In adrenocortical response to exogenous ACTH, double treatments with 100 μg/kg of dexamethasone resulted in lesser secretion rates of 11-OHCS than a single treatment. These findings would suggest the adrenal cortex as one of the sites of inhibition.
URI: http://hdl.handle.net/10069/15563
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 15, No. 1-4

Citable URI : http://hdl.handle.net/10069/15563

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