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Ultrastructural Studies of Experimental Arteriosclerosis Arterial Lesions Produced by Hemodynamic Change


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Title: Ultrastructural Studies of Experimental Arteriosclerosis Arterial Lesions Produced by Hemodynamic Change
Authors: Taura, Seiya
Authors (alternative): 田浦, 晴也
Issue Date: 25-Oct-1971
Citation: Acta medica Nagasakiensia. 1971, 16(1-2), p.38-58
Abstract: Sudden change of blood stream is considered as one of the pathological factors of arteriosclerosis. Rabbits were subjected to the dissection of the bilateral common carotid arteries and were sacrificed at certain time intervals. Observation was made for the behavior of the mural cells of the arteries in the cerebral basilar arterial system. One week after the operation, some media smooth muscle cells beneath the internal elastic lamina became irregular shape, and two weeks after the operation, they were even advanced to the state of coagulation necrosis showing marked increase of electron density in the cytoplasm. About the same time, the subendothelial space was immigrated by the media smooth muscle cells through the fenestrae of the internal elastic lamina, and thus intimal thickening was produced. At the advanced stage of experiment, medial thinning due to destruction and absorption of media smooth muscle cells became remarkable, but intimal thickening was not greatly intensified. As a result, the arteries showed dilatative lesion rather than stenosis of intimal thickening. The presence of a peculiar structure called Willis' ring in the cerebral basilar arterial system could not neglect as another cause of the dilatative lesion.
URI: http://hdl.handle.net/10069/15568
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 16, No. 1-2

Citable URI : http://hdl.handle.net/10069/15568

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