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Influence of the Excessive Intake of Monosodium L-Glutamate on the Growth and the Livers of Albino Rats


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タイトル: Influence of the Excessive Intake of Monosodium L-Glutamate on the Growth and the Livers of Albino Rats
著者: Oka, Kazuko / Suwa, Noriko / Nishimori, Issei
著者(別表記) : 岡, 和子 / 諏訪, 紀子 / 西森, 一正
発行日: 1974年 3月25日
引用: Acta medica Nagasakiensia. 1974, 18(1-4), p.26-34
抄録: It is already known that the excessive administration of monosodium L-glutamate (MSG) will cause various symptoms, and that the overmuch ingestion of amino acids will also give rise to liver disturbances. In the present study, MSG was administered to albino rats orally at varied concentrations, and its influences on the animals' growth and on their livers were examined. In the group given a 1 % MSG solution, the deviation of the body-weight began to enlarge on about the 30th day, because some of the individuals had an inclination to grow corpulent. The vitamin A content of the liver from this group was larger than that from the control group. In the examination of the liver tissue specimens, a little fatty degeneration assumed to be due to toxication was observed, but it seemed not to be so severe as to impede liver function. In the group given a 5% MSG solution, some were thinner than the individuals of the 1 % group. The vitamin A content of the liver from this group was smaller than that from the control group. In some individuals in this group, their body coats turned brown in some spots, with some hairs falling off. Some of the liver tissue cells were attacked by necrosis, showing secondary fatty degeneration. The degeneration was presumed to be caused by toxication. In the group given a 10 MSG solution, all the individuals died by the 5th day. Their body coats had turned brown with a great many hairs falling off.
URI: http://hdl.handle.net/10069/15576
ISSN: 00016055
資料タイプ: Departmental Bulletin Paper
原稿種類: publisher
出現コレクション:Volume 18, No. 1-4

引用URI : http://hdl.handle.net/10069/15576

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