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Pathogenesis of the Lesions of Glomerulus and Renal Arteriole in Experimental Hypertension


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Title: Pathogenesis of the Lesions of Glomerulus and Renal Arteriole in Experimental Hypertension
Authors: Moriyama, Nobuo
Authors (alternative): 森山, 信男
Issue Date: 25-Mar-1975
Citation: Acta medica Nagasakiensia. 1975, 19(1-4), p.59-81
Abstract: Electron microscopic studies were carried out in pursuit of the difference and interrelationship between the changes of the basement membrane of renal glomerulus and the changes of the basement membrane of renal arteriole in experimental hypertension. The changes of the basement membrane of arteriole and basement membrane like material of mesangium and lacis show their occurrence at about the same time and their progress in the same degree. The changes first observed are the beads-like thickening and reticular change of the basement membrane of vascular wall and also the increase of basement membrane like material in mesangium and lacis. These changes are followed by the deposit of dense material and fibrin on the vascular wall and the increase of basement membrane like material of mesangium and lacis so as to compress their cells and tear them to pieces. About this stage, the thickening of the basement membrane of glomerular capillary loop is intensified and moreover the wrinkle and tortuosity of the basement membrane of glomerular capillary loop and the collapse of glomerular capillary lumen became remarkable. The above findings suggest that the basement membrane of renal arteriole and the basement membrane like material of mesangium and lacis are interrelated, and may be the portions in the kidney most liable to changes and injury in hypertension.
URI: http://hdl.handle.net/10069/15583
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 19, No. 1-4

Citable URI : http://hdl.handle.net/10069/15583

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