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An Ultrastructural Study on Morphogenesis of Early Vascular Lesions Produced by Renal Cortical Extract


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タイトル: An Ultrastructural Study on Morphogenesis of Early Vascular Lesions Produced by Renal Cortical Extract
著者: Shiroma, Seikoh
発行日: 1977年 3月25日
引用: Acta medica Nagasakiensia. 1976, 21(1-4), p.1-26
抄録: Non-pressor renal vascular injurious factor was injected intravenously to bilaterally nephrectomized rats, utilizing ferritin particles as a tracer. Early vascular lesions within 24 hours were observed mainly by electron microscope. Striking features of endothelial cells in mesenteric and pancreatic arteries responsible for increased permeability, namely, the separations of intercellular junctions and denudation of endothelial layer were recognized. In consequence, serous component and ferritin particles, rarely accompanied by platelets, erythrocytes and polynuclear leukocytes penetrated into the media, in which fibrin deposits were focally exhibited. Two types of medial smooth muscle cell injury were observed, that is, only remarkably reduced cells displaced by the penetrated material and electron-lucent cells. Not rarely, there was also some changes of intercellular matrix. Some differences in morphological appearance between arteriolar and larger arterial lesions were revealed.
URI: http://hdl.handle.net/10069/15587
ISSN: 00016055
資料タイプ: Departmental Bulletin Paper
原稿種類: publisher
出現コレクション:Volume 21, No. 1-4

引用URI : http://hdl.handle.net/10069/15587

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