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An Ultrastructural Study on Morphogenesis of Early Vascular Lesions Produced by Renal Cortical Extract


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Title: An Ultrastructural Study on Morphogenesis of Early Vascular Lesions Produced by Renal Cortical Extract
Authors: Shiroma, Seikoh
Issue Date: 25-Mar-1977
Citation: Acta medica Nagasakiensia. 1976, 21(1-4), p.1-26
Abstract: Non-pressor renal vascular injurious factor was injected intravenously to bilaterally nephrectomized rats, utilizing ferritin particles as a tracer. Early vascular lesions within 24 hours were observed mainly by electron microscope. Striking features of endothelial cells in mesenteric and pancreatic arteries responsible for increased permeability, namely, the separations of intercellular junctions and denudation of endothelial layer were recognized. In consequence, serous component and ferritin particles, rarely accompanied by platelets, erythrocytes and polynuclear leukocytes penetrated into the media, in which fibrin deposits were focally exhibited. Two types of medial smooth muscle cell injury were observed, that is, only remarkably reduced cells displaced by the penetrated material and electron-lucent cells. Not rarely, there was also some changes of intercellular matrix. Some differences in morphological appearance between arteriolar and larger arterial lesions were revealed.
URI: http://hdl.handle.net/10069/15587
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 21, No. 1-4

Citable URI : http://hdl.handle.net/10069/15587

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