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Ultrastructural Study of the Dorsal Root Ganglia in Fetal Organic Mercury Intoxicated Rats


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Title: Ultrastructural Study of the Dorsal Root Ganglia in Fetal Organic Mercury Intoxicated Rats
Authors: Kishikawa, Masao
Authors (alternative): 岸川, 正大
Issue Date: 25-Oct-1977
Citation: Acta medica Nagasakiensia. 1977, 22(1-2), p.50-62
Abstract: Methylmercuric chloride (MeHg) was given in pregnant rats during the last week of gestation. Newborn and infant rats treated with MeHg during intrauterine life were sacrificed at birth, and 5th, 10th and 30th day after birth. Dorsal root ganglia (DRG) of the baby rats were examined light and electron microscopically. The neurons were more various in shape and had eccentric nuclei more often than these in control baby rats. Interface between the neurons and their satellite cells showed less interdigitations even at 30 days of age. The rough endoplasmic reticulum (RER) was shortened with dilated cisternae and irregular branching. At 30-day-old rat, the dilated endoplasmic reticulum was decreased in number. The alterations of RER are an evidence of morphological aspects for the protein synthesis decreasing. By 10th day, the neurofibrils were not so prominent in DRG neurons of MeHg treated rat at 5th day, while they were increased in number to form fibrillar bundle and separated the RER into small stacks at 30 days of age. This may reflect early, ongoing regenerative changes in injured DRG neurons. The DRG from the MeHg-baby rats disclosed extensive injuries of neurons, associated with developmental retardation of the ganglia.
URI: http://hdl.handle.net/10069/15596
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 22, No. 1-2

Citable URI : http://hdl.handle.net/10069/15596

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