DSpace university logo mark
詳細検索
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > 030 医学部 > 030 紀要 > Acta Medica Nagasakiensia > Volume 22, No. 1-2 >

Prostaglandin Involvement in the Endocrine Activity of the Testis


ファイル 記述 サイズフォーマット
acta22_01_04_t.pdf1.15 MBAdobe PDF本文ファイル

タイトル: Prostaglandin Involvement in the Endocrine Activity of the Testis
著者: Amano, Akio
著者(別表記) : 天野, 彰夫
発行日: 1977年10月25日
引用: Acta medica Nagasakiensia. 1977, 22(1-2), p.78-97
抄録: The effects of prostaglandins (PGE_2 and PGF_<2α>) on the secretory activity of the testis were investigated in mature male dogs. The secretory activity was determined by measuring 17-oxosteroids in spermatic vein blood. Seventeen-oxosteroid secretion in animals which received either PGE_2 (5 μg/kg) or PGF_<2α>(5 μg/kg)into the testicular tissue had increased distinctly within 20 minutes after the administration. Concomitantly blood flow through the spermatic vein increased to 3.4 times of preinjection levels 5 minutes after the injection of either prostaglandin. However, neither of these events occurred when either prostaglandin (10 μg/kg) was given by intravenous route. When either prostaglandin (1 μg/kg) was given intratestically at the time when the rate of testicular 17-oxosteroid secretion caused by an intravenous injection of human chorionic gonadotrophin (HCG, 20 i.u./kg) was at a maximum, the response to HCG was significantly augmented by PGE_2 but not by PGF_<2α>. With higher doses(10μg/kg)the potentiating effect of either prostaglandin was observed, but PGF_<2α> was considerably less active than PGE_2. Blood flow of the spermatic vein increased by either prostaglandin but the effect of PGF_<2α> was extremely weak. Administration into the testicular tissue of adenosine-3' , 5'-cyclic monophosphoric acid (cyclic AMP, 1 mg/kg) in combination with PGE_2 (5 μg/kg) produced marked increases in 17-oxosteroid secretion and spermatic vein blood flow. The combined effect was significantly greater than that of PGE_2 alone. However, these events were not observed in combination with PGF_<2α>(5μg/kg). Pretreatment with indomethacin (30 mg/kg), a potent inhibitor of prostaglandin synthesis, diminished the 17-oxosteroid secretory response to HCG (20 i.u./kg), but failed to inhibit the response to cyclic AMP (1 mg/kg).
URI: http://hdl.handle.net/10069/15598
ISSN: 00016055
資料タイプ: Departmental Bulletin Paper
原稿種類: publisher
出現コレクション:Volume 22, No. 1-2

引用URI : http://hdl.handle.net/10069/15598

このリポジトリに保管されている文献はすべて著作権により保護されています。
印刷やダウンロード等データの複製は、調査研究・教育または学習を目的とする場合に限定されます。

 

Valid XHTML 1.0! Copyright © 2006-2015 長崎大学附属図書館 - お問い合わせ Powerd by DSpace