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Prostaglandin Involvement in the Endocrine Activity of the Testis


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Title: Prostaglandin Involvement in the Endocrine Activity of the Testis
Authors: Amano, Akio
Authors (alternative): 天野, 彰夫
Issue Date: 25-Oct-1977
Citation: Acta medica Nagasakiensia. 1977, 22(1-2), p.78-97
Abstract: The effects of prostaglandins (PGE_2 and PGF_<2α>) on the secretory activity of the testis were investigated in mature male dogs. The secretory activity was determined by measuring 17-oxosteroids in spermatic vein blood. Seventeen-oxosteroid secretion in animals which received either PGE_2 (5 μg/kg) or PGF_<2α>(5 μg/kg)into the testicular tissue had increased distinctly within 20 minutes after the administration. Concomitantly blood flow through the spermatic vein increased to 3.4 times of preinjection levels 5 minutes after the injection of either prostaglandin. However, neither of these events occurred when either prostaglandin (10 μg/kg) was given by intravenous route. When either prostaglandin (1 μg/kg) was given intratestically at the time when the rate of testicular 17-oxosteroid secretion caused by an intravenous injection of human chorionic gonadotrophin (HCG, 20 i.u./kg) was at a maximum, the response to HCG was significantly augmented by PGE_2 but not by PGF_<2α>. With higher doses(10μg/kg)the potentiating effect of either prostaglandin was observed, but PGF_<2α> was considerably less active than PGE_2. Blood flow of the spermatic vein increased by either prostaglandin but the effect of PGF_<2α> was extremely weak. Administration into the testicular tissue of adenosine-3' , 5'-cyclic monophosphoric acid (cyclic AMP, 1 mg/kg) in combination with PGE_2 (5 μg/kg) produced marked increases in 17-oxosteroid secretion and spermatic vein blood flow. The combined effect was significantly greater than that of PGE_2 alone. However, these events were not observed in combination with PGF_<2α>(5μg/kg). Pretreatment with indomethacin (30 mg/kg), a potent inhibitor of prostaglandin synthesis, diminished the 17-oxosteroid secretory response to HCG (20 i.u./kg), but failed to inhibit the response to cyclic AMP (1 mg/kg).
URI: http://hdl.handle.net/10069/15598
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 22, No. 1-2

Citable URI : http://hdl.handle.net/10069/15598

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