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Epidemiological Study of Hepatitis B Virus in Nagasaki Area of Japan


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Title: Epidemiological Study of Hepatitis B Virus in Nagasaki Area of Japan
Authors: Tanaka, Yoshito
Authors (alternative): 田中, 義人
Issue Date: 25-Aug-1978
Citation: Acta medica Nagasakiensia. 1978, 23(1-4), p.1-13
Abstract: The epidemiological studies of Hepatitis B Virus (HBV) in Nagasaki Prefecture wellknown for the high incidence of liver cirrhosis, primary hepatoma and other liver diseases have been carried out by means of detecting several viral and related markers, such as the surface antigen of HBV (HBs Ag), the antibody to HBs Ag (anti-HBs), the antibody to the core of HBV(anti-HBc), e antigen(e Ag)and the antibody to e Ag(anti-e), in the sera among healthy blood donors, healthy inhabitants and hospitalized patients. HBs Ag was detected in 3.8% of 15,149 healthy persons (blood donors and inhabitants) and in 4.8% of 1,192 patients by means of immunoelectrosyneresis (IES). The positive rate (3.8%) in healthy persons was apparently higher than that in those of other areas in Japan. 1.1% of healthy persons and 5.9% of hospitalized patients were found to be anti- HBs-positive by IES. The HBs Ag-positive frequency was significantly higher in male than in female, but the anti-HBs-positive frequency was lower in male than in female. Dividing Nagasaki Prefecture into five areas, i. e. , Nagasaki City, Gotoh islands, the North, the East and the West areas, the prevalence of HBs Ag tended to be higher in the West and lower in the East. Especially, the positive occurence of HBs Ag in Gotoh area showed the highest value. Among subtypes of 359 HBs Ag-positive donor sera, HBs-antigenic determinants d (d,99%;y,1%)and γ(γ,93%;ω,7%)were dominant. The positive frequencies of e Ag and anti-e in 297 HBs Ag-positive donor sera were 53(17.8%)and 141(47.5%)respectively. Both e Ag and anti-e(e markers)were never detected in HBs Ag-negative sera. No relationship was found between the presence of e markers and HBs Ag subtypes. Although no HBc Ag was detected in any sera tested, anti-HBc was detected in all three classified groups of sera, i. e., negative group for both HBs Ag and anti-HBs, positive group for only anti-HBs, and positive group for only HBs Ag. In the first group, 17.7% of samples was anti-HBc-positive, and 81.3% and 100% of samples in the second
URI: http://hdl.handle.net/10069/15602
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 23, No. 1-4

Citable URI : http://hdl.handle.net/10069/15602

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