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Vascular Lesions Produced by Transient Renal Ischemia


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Title: Vascular Lesions Produced by Transient Renal Ischemia
Authors: Tomita, Shinichi
Authors (alternative): 冨田, 伸一
Issue Date: 25-Aug-1978
Citation: Acta medica Nagasakiensia. 1978, 23(1-4), p.47-62
Abstract: It has been clarified by the studies of our laboratory that the renal cortical extract of normal rats and experimentally hypertensive rats contain vascular injurious factors in addition to pressor substances. For the purpose of demonstrating this evidence in vivo, observations were made mostly of mesenteric and pancreatic vessels upon performing unilateral nephrectomy and contralateral renal arterial and ureteral ligations and releasing the arterial ligation after 2 hours and the ureteral ligation after 24 hours. As the result of transient renal ischemia, abnormalities of electrolytes, serum blood urea nitrogen and creatinine were recognized but these were gradually recovered. For eliminating pressor factors, rats without significant increase of blood pressure were used for the study. One day after the surgery, fibrinoid degeneration appeared in the media of arterioles and small arteries. This change developed with time into angiitis and panarteritis like lesions on the seventh day after the surgery. These vascular lesions were basically the same as those caused by the renal cortical extract. Accordingly, the vascular lesions resulting from transient renal ischemia were deemed to be caused by renal vascular injurious substances in vivo.
URI: http://hdl.handle.net/10069/15607
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 23, No. 1-4

Citable URI : http://hdl.handle.net/10069/15607

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