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Histometrical Approach of Aging Processes on Rat Aorta Using Low Power Magnification: Photographs of Electron Microscopy

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タイトル: Histometrical Approach of Aging Processes on Rat Aorta Using Low Power Magnification: Photographs of Electron Microscopy
著者: Toda, Takayoshi
著者(別表記) : 戸田, 隆義
発行日: 1978年 8月25日
引用: Acta medica Nagasakiensia. 1978, 23(1-4), p.63-81
抄録: 72 Wistar Strain rats ranging in age from new born to age of 3 years were used to clarify specificity in growth of aorta in aging processes of vascular system. Developmental transformation of aortic media was investigated using low power magnification photographs of electron microscopy (x 850), because cell membrane can be traced easily. Number and size of smooth muscle cells, density of intercellular material and elastic fiber in a given unit area were histometrically estimated. In addition the fine structural study of each components of aorta was performed. In growing rat aorta, atypical biphasic pattern with double peak was observed in total intercellular material density around postnatal 5th and 35th day. Number of smooth muscle cell of aorta decreased with aging, and size of smooth muscle cell of aorta showed peak around 50th day. Smooth muscle cell of aortic media from newborn rat showed secretary function with organella-rich cytoplasm. Around 50th day after birth, transitory smooth muscle cell from organella-rich secretary cells to contractile cells with a large amount of myofibril was seen in proportion of one tenth in a given unit area. Rat aortic media maintained high level in density of elastic fiber per unit area from 30th to 60th day. During involutional period, fluctuation of total intercellular material density in rat aortic media was not obvious. However, detailed analyis of each component of aortic media revealed that decrease in number of smooth muscle cells and density of elastic fiber density developed, but cell debris increased. From the view point of acceleration of pubescence, it was considered to be of interest finding that atypical biphasic pattern was observed in alteration of total intercellular material density of rat aortic media during growth.
URI: http://hdl.handle.net/10069/15608
ISSN: 00016055
資料タイプ: Departmental Bulletin Paper
原稿種類: publisher
出現コレクション:Volume 23, No. 1-4

引用URI : http://hdl.handle.net/10069/15608



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