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Clinical Evaluation of Immune Response in Patients with Cancer


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Title: Clinical Evaluation of Immune Response in Patients with Cancer
Authors: Tomita, Masao / Koga, Yasunori / Shibata, Koichiro / Matsumoto, Kazuhisa / Onizuka, Toshio / Sakoda, Koichiro / Maeda, Takami / Hamasuna, Shigehito / Wake, Norio / Ichinose, Yukito
Authors (alternative): 富田, 正雄 / 古賀, 保範 / 柴田, 紘一郎 / 松本, 和久 / 鬼塚, 敏男 / 迫田, 耕一朗 / 前田, 隆美
Issue Date: 25-Oct-1979
Citation: Acta medica Nagasakiensia. 1979, 24(1-4), p.32-39
Abstract: Immune response was clinically evaluated in 25 patients with carcinoma compared with 26 of non cancer patients by means of lymphocyte transformation against PHA which was shown as stimulation index. In patients with cancer, stimulation index showed apparently as low as an average of 38 compared with 82 of non-cancer patients. Furthermore, the level of stimulation index was a corresponding correlation to age in which low activation was presented in the elderly. According to diseased organs, the weak response of stimulation index against PHA were observed in patients with the carcinoma of the esophagus and the lung. The response of skin test for PPD, PHA, SK-SD and candida were inhibited in patients with advanced cancer of stage III and IV compared with that of stage I and II. These responses were also suppressed in postoperative course until at least 6 months after surgery. From these results, it was noted that operative procedures provoked the induced weakness against host defense immunologically. However, it was certified that the use of immunopotentiator faciliated the activity of immune response during postoperative period for the patients with no severely advanced lung cancer of stage I and II despite of little effects for patients with advanced lung cancer of stage III and IV. It was concluded that immune response of patients with cancer was inhibited by advancing carcinoma and by operative procedures but the use of immunopotentiator was beneficial to promote the host defense during postoperative period.
URI: http://hdl.handle.net/10069/15613
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 24, No. 1-4

Citable URI : http://hdl.handle.net/10069/15613

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