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Clinical Evaluation of Immune Response in Patients with Lung Cancer


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Title: Clinical Evaluation of Immune Response in Patients with Lung Cancer
Authors: Tomita, Masao / Koga, Yasunori / Shibata, Koichiro / Matsumoto, Kazuhisa / Onitsuka, Toshio / Sakoda, Koichiro / Maeda, Takami / Hamasuna, Shigehito / Kariya, Toshiro / Matsuzaki, Yasunori / Yonezawa, Tsutomu / Yoshioka, Makoto
Authors (alternative): 富田, 正雄 / 古賀, 保範 / 柴田, 紘一郎 / 松本, 和久 / 鬼塚, 敏男 / 迫田, 耕一郎 / 前田, 隆美 / 浜砂, 重仁 / 仮屋, 敏郎 / 松崎, 泰憲 / 米沢, 勤 / 吉岡, 誠
Issue Date: 25-Oct-1980
Citation: Acta medica Nagasakiensia. 1980, 25(1-4), p.8-15
Abstract: In patients with lung cancer, the immune response was observed with an analysis of various factors which mostly related to its prognosis. Its response was extremly depressed in the course of following surgery in advanced cases of stage III and IVas well as in unresectable cases for lung cancer, compared with those of stage I and II . Furthermore, it showed that the high levels of immune response were seen in those of long term survivors given OK-432 during follow-up period. It was obvious from this study that the use of OK-432 was suitable for activation of the immune reaction against host as one of the immunopotentiators. Meanwhile, from the immunological mechanism of view, the hyperactivity of immune response enable the patient to be free from recurrence of cancer for a long term following surgery, in contrast the low level of the immune response showed to be poor prognosis owing to early appearance of recurrence. Furthermore, the effectiveness in use of OK-432 was clinically presented in patients with malignant pleural effusion, which showed direct cytocidal action of OK-432 given intrapleurally with a 10 or 14 days interval.
URI: http://hdl.handle.net/10069/15621
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 25, No. 1-4

Citable URI : http://hdl.handle.net/10069/15621

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