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Experimental Evaluation of Tumor Inhibitory Effect of Induced Infection on Tumor Growth

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Title: Experimental Evaluation of Tumor Inhibitory Effect of Induced Infection on Tumor Growth
Authors: Koga, Yasunori / Tomita, Masao / Shibata, Koichiro / Matsumoto, Kazuhisa / Onitsuka, Toshio / Sakoda, Koichiro / Maeda, Takami / Hamasuna, Shigehito / Wake, Norio / Sakihama, Masato / Tashiro, Hikaru / Mine, Yoshikazu / Chiyotanda, Susumu / Matsuzaki, Yasunori / Yonezawa, Tsutomu / Yoshioka, Makoto
Authors (alternative): 古賀, 保範 / 富田, 正雄 / 柴田, 紘一郎 / 松本, 和久 / 鬼塚, 敏男 / 迫田, 耕一朗 / 前田, 隆美 / 浜砂, 重仁 / 和気, 典雄 / 崎浜, 正人 / 田代, 光 / 峰, 義和 / 千代反田, 晋 / 松崎, 泰憲 / 米沢, 勤 / 吉岡, 誠
Issue Date: 25-Oct-1981
Citation: Acta medica Nagasakiensia. 1981, 26(1-4), p.9-14
Abstract: To evaluate as to whether coexisting infection is helpful to achieve the tumor regression, the inhibitory effect was experimentally assessed from the view point of survival, the degrees of reticuloendothelial activation (Congo-red clearance test) and immune response (Jerne' plaque forming cell test and macrophage migration inhibition test). A 3×107 to 2×108 of β-streptococcus inoculated in C3H mice of 6 week-old were prepared for producing a varying models of infection. As a control study, survival challenging for a 1X106 of Ehrlich tumor inoculation was surveyed. It averaged 16.6 days, whereas it increased when added infection. The most longest survival was 24.4 days when infection was provoked when a 3×107 β-streptococcus were inoculated subcutaneously 5 days prior to Ehrlich tumor cell implantation. Phagocytic activity in the recticuloendothelial system was found to be consequent of stimulation by the varying variety of infection. To assess the inhibitory effect of induced infection on tumor growth, a directly weighing method was applied for inoculated methylcholantrene tumor at interval of 5 days. It is proved that infection is more effective in depressing tumor growth. Furthermore, our experiment indicated that infection enabled the host to enhance the immune response to various antigen, which might be originated from the reticuloendothelial hyperactivity. As the result of this study, we concluded that a mild and long-standing infection might play a key role in inhibiting tumor growth to some extent.
URI: http://hdl.handle.net/10069/15630
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 26, No. 1-4

Citable URI : http://hdl.handle.net/10069/15630

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