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Suspected Case of Combined Immunodeficiency Autopsy Case


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Title: Suspected Case of Combined Immunodeficiency Autopsy Case
Authors: Kawai, Kioko / Gyotoku, Yutaka / Noda, Hiroyuki / Tsuchiyama, Hideo
Authors (alternative): 河合, 紀生子 / 行徳, 豊 / 野田, 弘之 / 土山, 秀夫
Issue Date: 25-Oct-1981
Citation: Acta medica Nagasakiensia. 1981, 26(1-4), p.26-37
Abstract: An autopsy case of combined immunodeficiency of 3 year 11 months old boy is presented. He had stomatitis, chronic protracted diarrhea, fever, growth retardation which are characteristic symptomes in severe combined immunodeficiency (SCID). IgA was low and IgG and IgM decreased towards the terminal stage. SK-SD skin reaction was negative and DNCB sensitized skin reaction was negative indicating the lack of delayed type of hypersensitivity. Compared to the typical case of primary immunodeficiency, the degree of abnormality of humoral and cellular immune functions is milder in this case. Autopsy revealed the remaining lymph nodes and histologically formation of lymphoid follicles was not distinct and lymphocyte depletion in thymic-dependent area was seen. These lesions varied in degrees depending on the location within the lymph nodes. Thymus weighed 2.2g and had Hassal's corpuscles with calcification. These findings are somewhat different from the typical case of primary immunodeficiency. We consider this case as suspected case or borderline case of combined immunodeficiency by correlation of clinical and histopathological aspect. Generalized cytomegalic inclusion disease is this direct cause of death.
URI: http://hdl.handle.net/10069/15632
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 26, No. 1-4

Citable URI : http://hdl.handle.net/10069/15632

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