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Studies on the Effects of Growth Hormone on the Retinal Vascular Elements of Streptozotocin Induced Diabetic Rats


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Title: Studies on the Effects of Growth Hormone on the Retinal Vascular Elements of Streptozotocin Induced Diabetic Rats
Authors: Tsuda, Naoyuki / Takaku, Isao
Authors (alternative): 津田, 尚幸 / 高久, 功
Issue Date: 25-Oct-1981
Citation: Acta medica Nagasakiensia. 1981, 26(1-4), p.73-81
Abstract: The morphologically characteristic changes were irregular thickening of the basement membrane in the streptozotocin induced diabetic group (S rats) and more striking irregular hypertrophy of the same membrane in the group further administered with growth hormone (S+BGH rats). In the outer basement membrane surrounding the pericytes of S rats and S+BGH rats retinal capillary, and deposit of elastine could be suggested, which were seen as electron lucid, were proved by tannic acid stainning to be substances with high electron density. Biochemical assay disclosed that the characteristic change was a marked increase in hydroxyproline in the group with diabetes and an increase in hexosamine and also in sialic acid in the group further administrated with growth hormone. In view of the above finding, it was considered that substances of the collagen group are involved in the thickening of the basement membrane in diabetes, and that the loading with growth hormone is influential on glycoproteins deposition.
URI: http://hdl.handle.net/10069/15635
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 26, No. 1-4

Citable URI : http://hdl.handle.net/10069/15635

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