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Experimental Hypertension: Pathological Study of the Cerebrovascular Lesions of Stroke-prone Spontaneously Hypertensive Rat (SHR-SP)


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Title: Experimental Hypertension: Pathological Study of the Cerebrovascular Lesions of Stroke-prone Spontaneously Hypertensive Rat (SHR-SP)
Authors: Takiguchi, Kenro
Authors (alternative): 瀧口, 健郎
Issue Date: 25-Oct-1983
Citation: Acta medica Nagasakiensia. 1983, 28(1-4), p.46-63
Abstract: There have been two views concerning that cerebrovascular lesion in spontaneously hypertensive rat (SHR-SP) would correspond to which model for human hypertensive cerebrovascular lesions. One is that it corresponds to a model for human benign hypertension, while the other is that it corresponds to a that for human malignant hypertension. The Author examined the serial sections prepared from the brains of SHR-SP, and compared them with those of cerebrovascular lesions of the human cases dead of uremia due to malignant hypertension and of the human cases dead of complications with cerebral hemorrhage due to malignant hypertension. The results revealed that as to the cerebral infarctions in SHR-SP, small infarctions fuse and form one large infarctions, and they were caused by fibrinoid necrosis and microthrombus of endarterioles and capillaries. In addition, the lesions of massive cerebral hemorrhage resulted from ruptures of microaneurysms of small arteries, 100 to 130 μ in diameter. In other words, the cerebral infarctions were identical to the changes of human malignant hypertension, and the massive cerebral hemorrhage was closely similar to the form of cerebral hemorrhage of human benign hypertension. The fact in SHR-SP suggested that the cases of cerebral infarction were models for human malignant hypertension. And it also suggested that the cases of cerebral hemorrhage or those additionally complicated with cerebral infarction were models for malignant phase of human benign hypertension.
URI: http://hdl.handle.net/10069/15640
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 28, No. 1-4

Citable URI : http://hdl.handle.net/10069/15640

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