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Efficacy of Coenzyme Q10 Administration in Experimentally Created Aortic Stenosis and Pacemaker Induced Tachycardia Katsuro IGARASHI


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Title: Efficacy of Coenzyme Q10 Administration in Experimentally Created Aortic Stenosis and Pacemaker Induced Tachycardia Katsuro IGARASHI
Authors: Igarashi, Katsuro
Authors (alternative): 五十嵐, 勝朗
Issue Date: 25-Oct-1984
Citation: Acta medica Nagasakiensia. 1984, 29(1-4), p.7-15
Abstract: IGARASHI, K. Efficacy of Coenzyme Q10 Administration in Experimentally Created Aortic Stenosis and Pacemaker Induced Tachycardia. Acta Med. Nagasaki., 1984. For the purpose of studying how CoQ10 exerts effect in case of the oxygen demand being increased, we opened the chests of 7 mongrel dogs after anesthesia, made a simultaneous recording of PLV, PAO, PLVED, CBF, ABF and ECG, created aortic stenosis experimentally, had tachycardia induced by atrial pacing and studied the oxygen extraction and lactate uptake at the time. In aortic stenosis, it was suggested that the aerobic metabolism would be under way with the PLV-PAO pressure gradient of about 30mmHg. In tachycardia 1.5 times the basic heart beat, meanwhile, a distinct fall in the lactate uptake was seen in 2 out of 7 cases, and this fall diminished after administration of CoQ10. Thus it was suggested that CoQ10 would suppress the anaerobic production of energy and improve the energy metabolism. (key words, Coenzyme Q10, aortic stenosis, tachycardia)
URI: http://hdl.handle.net/10069/15652
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 29, No. 1-4

Citable URI : http://hdl.handle.net/10069/15652

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