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Histochemical and Morphological Characteristics in Cultures of Normal Human Adrenal Cortex and Adrenocortical Tumors


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Title: Histochemical and Morphological Characteristics in Cultures of Normal Human Adrenal Cortex and Adrenocortical Tumors
Authors: Matsuo, Kenji
Authors (alternative): 松尾, 健治
Issue Date: 25-Oct-1984
Citation: Acta medica Nagasakiensia. 1984, 29(1-4), p.16-28
Abstract: Histochemical and morphological studies in culture were carried out on 4 cases from the normal human adrenal cortex (NHA), 1 case from CUSHING'S adenoma (CS), 4 cases from CONN'S adenoma (primary aldosteronism, PA) and 1 case from adrenocortical carcinoma (ACC). Cultured cells from CS and ACC transformed rapidly into fibroblast-like cells, while those from NHA and PA remained on the substratum as epithelial-like cells in the beginning but gradually changed into fibroblast-like cells. Cultured cells from CS and ACC were negative for oil red 0 staining, while lipid droplets in the cytoplasm were prominent in the PA-and NHA-cultured cells. Cells active for 3β-hydroxysteroid dehydrogenase(3β-HSD) were admixed among the ACC-cultured cells and present sporadically in the CS culture. In primary culture of PA and NHA, cells in early passage revealed activity for 3β-HSD but fibrobast-like cells hardly revealed activity. In all the cases, ultrastructural features of the cultured cells varied from those of the original cells, but the cultured cells were contacted each other with interdigitation and desmosome-like structures.
URI: http://hdl.handle.net/10069/15653
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 29, No. 1-4

Citable URI : http://hdl.handle.net/10069/15653

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