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Myocardial Protective Effects of Nicardipine Hydrocloride (Perdipine) in Glucose Potassium Cardioplegic Solution on Isolated Rat Heart

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タイトル: Myocardial Protective Effects of Nicardipine Hydrocloride (Perdipine) in Glucose Potassium Cardioplegic Solution on Isolated Rat Heart
著者: Kawabe, Hideaki
著者(別表記) : 河部, 英明
発行日: 1985年10月25日
引用: Acta medica Nagasakiensia. 1985, 30(1-3), p.139-155
抄録: The effect on myocardial protection against ischemic damage by addition of the Ca antagonist perdipine (nicardipine) at 0.25mg/L, and 0.5mg/L, to cardioplegic solution on isolated rat heart was assessed by hemodynamic studies, the time required to achieve resuscitation, CPK assay, and histologic evaluation. Twenty seven rat heart were divided into three groups of nine, with two experimental groups receiving different amounts of perdipine in the cardioplegic solution and group serving as control. Group 1 hearts (our control group) received glucose potassium cardioplegic solution (G. K. K ; 40mEq/L) Group 2 received nicardipine 0.25mg/L in addition to the standerd G. K. solution (G. P. K. 0.25). In the third group, the nicardipine dosage was increased to 0.5mg/L (Group 3; G. P. K. 0.5). Our results indicate that the addition of perdipine to cardioplegic solution provides significant protection against myocardial injury during ischemic arrest. The effect of perdipine (nicardipine) on hemodynamics was greatest in Group 2, although, Group 3 also demonstrated significant improvement with regard to several parameters. There were statistically significant differences between the control group (Group 1) and the experimental groups (2 and 3) with respect to Coronary Flow (CF p<0.01), Cardiac Output (CO p<0.05), and the time requiered to achieve resuscitation (p<0.01). Additionally, Groups 1 and 2 differed significantly with respect to Peak Systolic Pressure (PSP p<0.05) and Pressure Rate Product (PRP p<0.05). There were no significant differences between Groups 2 and 3. CPK levels were assayed in the three groups, with the average level of CPK in the coronary effluent increasing in the following order: Group 3< 2< 1, with the difference in levels being statistically significant betwee Groups 1 and 3 (p<0.05). Histological damage to the myocardium was mild; however, significant differences in the appearance of contraction bands in the walls of the septum and left ventricle were noted between the control group (1) versus the experimental groups (2 and 3) with p<0.05.
URI: http://hdl.handle.net/10069/15674
ISSN: 00016055
資料タイプ: Departmental Bulletin Paper
原稿種類: publisher
出現コレクション:Volume 30, No. 1-3

引用URI : http://hdl.handle.net/10069/15674



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