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Electronmicroscopic studies of parathyroid storage granules in the mouse (II) . -Effects of hypercalcemia


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Title: Electronmicroscopic studies of parathyroid storage granules in the mouse (II) . -Effects of hypercalcemia
Authors: Chen, Hong-Shing
Issue Date: 25-Oct-1988
Citation: Acta medica Nagasakiensia. 1988, 33(1-4), p.26-31
Abstract: Short-term effects of CaCl2-treatment on parathyroid cells of the mouse, especially on their storage granules, were studied at the ultrastructural level. After an injection of 2% CaCl2, serum calcium levels (SCL) rapidly increased from 9.9 mg/dl (controls) to a maximum of 12.4 mg/dl at 30 min, while the mean number of type-I storage granules which have a large core (NSG- I ) rapidly decreased and that of type-II storage granules which have a small core (NSG- II) increased significantly at 20 and 30 min. Vacuolar bodies containing no or small amounts of content also increased accompanying the augmented type- II storage granules. On the other hand the sum of NSG- I and NSG- II was restricted within narrow limits. Acid-phosphatase activity was occasionally found in storage granules of both types, especially in those of type- II and in vacuolar bodies. Such activities were more frequently detected in calcium- treated animals than in controls. It is concluded that type- I storage granules may be transformed into vacuolar bodies via type-II granules as a result of hydrolysis, and that these processes may be accelerated by hypercalcemia.
URI: http://hdl.handle.net/10069/15703
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 33, No. 1-4

Citable URI : http://hdl.handle.net/10069/15703

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