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Histochemical and Immunohistochemical Studies on the Relationship Between Severe Iron Accumulation and Liver Cell Injury


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タイトル: Histochemical and Immunohistochemical Studies on the Relationship Between Severe Iron Accumulation and Liver Cell Injury
著者: Senba, Masachika / Matsumura, Hidekatsu / Nakamura, Tsuyoshi / Itakura, Hideyo
発行日: 1988年10月25日
引用: Acta medica Nagasakiensia. 1988, 33(1-4), p.68-71
抄録: Histochemical and immunohistochemical analysis was carried out to determine the relationship between iron accumulation and hepatic cirrhosis, using 10 autopsy cases of. severe iron accumulation in the hepatocytes obtained from Kenya, including cases of Bantu siderosis. These severe iron accumulation specimens were divided into two groups ; one group consists of five cases with cirrhosis with or without hepatocellular carcinoma, and the other five cases with non-cirrhosis. All cirrhosis cases included hepatitis B surface antigen. Chronic infection caused by hepatitis B virus may lead to necrosis of the liver cells, resulting in the formation of hepatic fibrosis or cirrhosis. On the other hand, none of the non-cirrhosis cases include hepatitis B virus. This finding indicates that iron accumulation does not lead to cellular injury. Therefore, it is suggested that chronic iron toxicity is not recognized in Bantu siderosis. The reached conclusion is that there is no correlation between iron accumulation and hepatic fibrosis or cirrhosis.
URI: http://hdl.handle.net/10069/15709
ISSN: 00016055
資料タイプ: Departmental Bulletin Paper
原稿種類: publisher
出現コレクション:Volume 33, No. 1-4

引用URI : http://hdl.handle.net/10069/15709

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