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Biliary ICG Concentrations as an Indicatr of the Effect of Biliary Decompressions : Peak and two-hour ICG Concentrations

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Title: Biliary ICG Concentrations as an Indicatr of the Effect of Biliary Decompressions : Peak and two-hour ICG Concentrations
Authors: Oka, Susumu / Izawa, Kunihide / Segawa, Tohoru / Tsunoda, Tsukasa / Tsuchiya, Ryoichi
Issue Date: 25-Oct-1988
Citation: Acta medica Nagasakiensia. 1988, 33(1-4), p.72-82
Abstract: To quantitate the effects of biliary decompression on hepatic functional reserve prior to a definitive operation in patients with obstructive jaundice, indocyanine green (ICG) concentration in the bile was measured before and at 15 minute intervals for six hours following its administration. The maximal excretion rate of ICG in the bile as a function of time (ICG Bmax) was calculated by the following equation : ICG Bmax=loge (loge(10Xpeak concentration)] peak concentration time Determination of ICG Bmax has a shortcoming in that it requires prolonged restriction of the patients. Therefore, for the purpose of simplification, the natural logarithm of the ICG concentration two hours after ICG administration (ICG B2hr) was obtained : ICG B2hr=loge (biliary ICG concentration at two hours) There was a significant correlation between ICG Bmax and ICG B2hr' with a correlation coefficient of 0.865 as determined in 131 subjects. ICG Bmax is a reliable indicator in the assessment of hepatic functional reserve in jaundiced patients after biliary decompression and prior to further surgical interventions ICG B2hr assessment is a simplified method of ICG Bmax assessment. ICG B2hr values of less than 0.5 are considered to be contraindication for surgery, with a high probability of prolonged jaundice and poor prognosis. Values of more than 0.5 indicate the advisability of surgery, while those between -0.5 and 0.5 also indicate this if there is a trend to improvement.
URI: http://hdl.handle.net/10069/15710
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 33, No. 1-4

Citable URI : http://hdl.handle.net/10069/15710

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