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Comparison in the immune response between lung and kidney transplantation


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Title: Comparison in the immune response between lung and kidney transplantation
Authors: Honda, Shizuya
Issue Date: 25-Oct-1988
Citation: Acta medica Nagasakiensia. 1988, 33(1-4), p.102-109
Abstract: To know a difference in the immune responses between the lung and the kindly allo-transplantation, the humoral and cell bound antibody levels were compared by means of cytotoxic assay (CA) and Immune hemoagglutination (IA) test in dogs. 1) The humoral antibody levels were increased five to 10 days prior to appearance of rejection following lung transplantation in spite of maintaining relatively low levels in the course although it was different from kidney one. 2) On the other hand, the cell bound antibody levels were not increased in accordance with the rejection response at lung transplantation. Meanwhile, renal transplantation made the cell antibody levels higher with time in the humoral antibody levels, although cell-bound antibody levels were increased on day five to seven with a seven day maximum, thereafter gradually decreased to some extent. It is of considerable interest that a high humornal antibody levels had a close relation to death. 3) The administration of the antilymphocyte serum (ALS) was effective in suppressing the immune response showing the low humoral antibody levels and improved survival period. 4) Skin transplantation prior to lung or kidney transplantation kept high antibody titers on and after day four lung transplantation and on day seven to 10 at kidney. Conclusion was drawn from this study that skin and lung or kidney have the common cross reacting antigenicity to organ transplantation, in particular, the lung has a strong cross reacting antigenicity to the skin rather than the kidney.
URI: http://hdl.handle.net/10069/15715
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 33, No. 1-4

Citable URI : http://hdl.handle.net/10069/15715

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