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Evalution of la positive cells in the canine lung transplantation


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タイトル: Evalution of la positive cells in the canine lung transplantation
著者: Nakano, Yuusuke
発行日: 1988年10月25日
引用: Acta medica Nagasakiensia. 1988, 33(1-4), p.110-118
抄録: The rejection process related to Ia-positive cells consisting of the lymphocytes of bronchoalveolar lavage (BAL) was mainly evaluated at rejection of lung allotransplantation and also the inhibitory effect of CsA on occuring rejection is assessed. 1) In BAL taken from the transplanted lung, the increase in Ia positive rate and cell population was noted. Meanwhile in B-cells, activated T lymphocytes were remarkably increased in number. 2) The Ia positive rate in alveolar macrophages was the highest in the rejected lung. On the other hand in monocytes of the peripheral blood it was apparently reduced with statistical significance. 3) In virto study, the Ia positive rate of the lymphocytes in BAL was increased by PHA stimulation and significantly reduced by the addition of CsA. The Ia positive rate of macrophages in BAL also tended to be inhibited by adding CsA. The result enabled me to conclude that CsA acts as the elimination of Ia-positive rate in BAL lymphocytes and macrophages. 4) In the rejected lung a cluster of Ia-positive cells was seen not only around small vessels but in the alveolar space. Of interest is the fact that the role of Ia-positive cells is crucial to rejection of lung allografts.
URI: http://hdl.handle.net/10069/15716
ISSN: 00016055
資料タイプ: Departmental Bulletin Paper
原稿種類: publisher
出現コレクション:Volume 33, No. 1-4

引用URI : http://hdl.handle.net/10069/15716

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