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Morphometrical Study on the Sclerotic Inferior Vena Cava in Chronic Lung Disease


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Title: Morphometrical Study on the Sclerotic Inferior Vena Cava in Chronic Lung Disease
Authors: Ito, Masahiro / Hsu, Chao-Tien / Shikuwa, Saburo / Kawase, Yoshihisa / Matsumoto, Koji / Sekine, Ichiro / Fujii, Hideharu
Issue Date: 25-Oct-1988
Citation: Acta medica Nagasakiensia. 1988, 33(1-4), p.157-162
Abstract: The purpose of this study is to determine the relationship between chronic lung disease (CLD) and morphological changes in the inferior vena cava (IVC) from postmortem materials. The IVC and pulmonary truncus were obtained from 70 cases with CLD and/or cor pulmonale and from 23 controls. The tissues were processed for light and electron microscopic studies. The adventitia was by far the thickest component of the IVC wall. The total wall, intimal, and adventitial thicknesses were all significantly greater in the CLD cases than in the controls (p<0.001), but there was no significant difference in the ratio of adventitia thickness to wall thickness. The incidence of intimal thickening was 13.0% and 37.3% in controls and in CLD respectively. Electron microscopic examination of the IVC from the CLD cases revealeda marked increase in the amount of extracellular matrix including collagen, elastic fibers and ground substances in the adventitia as compared with the controls. No foam cells were detected in the thickened intima of the IVC. PA, right ventricular thickness and RV/LV ratio were greater in CLD than in controls. The blood gas levels of the CLD cases indicated obvious hypoxia (PaO2 54.2 mmHg). This study suggests that increased venous pressure and hypoxia might be implicated in the pathogenesis of phlebosclerosis in patients with CLD.
URI: http://hdl.handle.net/10069/15733
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 33, No. 1-4

Citable URI : http://hdl.handle.net/10069/15733

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