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NAOSITE : Nagasaki University's Academic Output SITE > School of Medicine > Bulletin > Acta Medica Nagasakiensia > Volume 34, No. 2-4 >

Morphogenesis of Aortico-pulmonary Septation Anomaly Induced by Bis-diamine Treatment Special reference to vimentin, desmin and fibronectin immunoreactivities


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Title: Morphogenesis of Aortico-pulmonary Septation Anomaly Induced by Bis-diamine Treatment Special reference to vimentin, desmin and fibronectin immunoreactivities
Authors: Kose, Noriyuki
Issue Date: 9-Dec-1989
Citation: Acta medica Nagasakiensia. 1989, 34(2-4), p.35-52
Abstract: In order to clarify the morphogenesis of the A-P septum, the conotruncal septum, the myocardial sheath and the smooth muscle cells of the great arteries in the normal hearts and bis-diamine induced cardiovascular anomalies, an immunohistochemical technique using the antibodies for vimentin, desmin and fibronectin was applied. Morphological and immunohistochemical changes in the treated hearts were as follows : (1) the A-P septum which was hypoplastic appeared later than in the normal hearts ; (2) retraction of the myocardial sheath was delayed compared with the normal hearts ; (3) switching from vimentin to desmin in the muscles of the atria and ventricles caused a delay of one day behind that of the normal hearts ; (4) vimentin immuno-reactivity in the smooth muscle cells of the pulmonary trunk was weaker than that of the aorta, and (5) weak reactivity of fibronectin occurred concomitant with weak vimentin reactivity. It is concluded that bisdiamine may induce the morphological anomalies of the A-P septation by inhibiting the production or perturbing the migration of neural crest cells which have been a precursor of the mesenchyme in the anlage of the A-P septum, subsequently by either inhibiting production or changing the nature of extracellular matrix, or by affecting the coordination of intermediate filaments.
URI: http://hdl.handle.net/10069/15760
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 34, No. 2-4

Citable URI : http://hdl.handle.net/10069/15760

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