DSpace university logo mark
詳細検索
Japanese | English 

NAOSITE : Nagasaki University's Academic Output SITE > 030 医学部 > 030 紀要 > Acta Medica Nagasakiensia > Volume 34, No. 2-4 >

Morphogenesis of Aortico-pulmonary Septation Anomaly Induced by Bis-diamine Treatment Special reference to vimentin, desmin and fibronectin immunoreactivities


ファイル 記述 サイズフォーマット
acta34_02_08_t.pdf11.93 MBAdobe PDF本文ファイル

タイトル: Morphogenesis of Aortico-pulmonary Septation Anomaly Induced by Bis-diamine Treatment Special reference to vimentin, desmin and fibronectin immunoreactivities
著者: Kose, Noriyuki
発行日: 1989年12月 9日
引用: Acta medica Nagasakiensia. 1989, 34(2-4), p.35-52
抄録: In order to clarify the morphogenesis of the A-P septum, the conotruncal septum, the myocardial sheath and the smooth muscle cells of the great arteries in the normal hearts and bis-diamine induced cardiovascular anomalies, an immunohistochemical technique using the antibodies for vimentin, desmin and fibronectin was applied. Morphological and immunohistochemical changes in the treated hearts were as follows : (1) the A-P septum which was hypoplastic appeared later than in the normal hearts ; (2) retraction of the myocardial sheath was delayed compared with the normal hearts ; (3) switching from vimentin to desmin in the muscles of the atria and ventricles caused a delay of one day behind that of the normal hearts ; (4) vimentin immuno-reactivity in the smooth muscle cells of the pulmonary trunk was weaker than that of the aorta, and (5) weak reactivity of fibronectin occurred concomitant with weak vimentin reactivity. It is concluded that bisdiamine may induce the morphological anomalies of the A-P septation by inhibiting the production or perturbing the migration of neural crest cells which have been a precursor of the mesenchyme in the anlage of the A-P septum, subsequently by either inhibiting production or changing the nature of extracellular matrix, or by affecting the coordination of intermediate filaments.
URI: http://hdl.handle.net/10069/15760
ISSN: 00016055
資料タイプ: Departmental Bulletin Paper
原稿種類: publisher
出現コレクション:Volume 34, No. 2-4

引用URI : http://hdl.handle.net/10069/15760

このリポジトリに保管されている文献はすべて著作権により保護されています。
印刷やダウンロード等データの複製は、調査研究・教育または学習を目的とする場合に限定されます。

 

Valid XHTML 1.0! Copyright © 2006-2015 長崎大学附属図書館 - お問い合わせ Powerd by DSpace