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Expression of EGF and, Ras and Myc Oncogene Products in Normal, Graves' Thyroid, Adenoma, and Carcinoma of the Thyroid


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タイトル: Expression of EGF and, Ras and Myc Oncogene Products in Normal, Graves' Thyroid, Adenoma, and Carcinoma of the Thyroid
著者: Toda, Takayoshi / Deguchi, Shigeru / Kurihara, Kohtaro / Hamada, Yuhshi / Muto, Yoshihiro / Kitsukawa, Keizo
発行日: 1989年12月 9日
引用: Acta medica Nagasakiensia. 1989, 34(2-4), p.70-75
抄録: An immunohistochemical study of EGF, and products of ras and myc oncogenes was carried out in 47 cases of non-neoplastic and neoplastic lesions of the thyroid. Normal thyroid tissues showed no significant immunostaining reaction to antibodies for EGF, and products of ras and myc oncogenes. The incidence of EGF positivity was 27%, 46% and 76% in Graves' disease, follicular adenoma, and carcinoma, repectively. The incidence of positivity of ras oncogene product was 27%, 38%, and 82% in Graves' disease, follicular adenoma and carcinoma, respectively. The incidence of positivity of myc oncogene product was 18%, 46% and 71% in Graves' disease, Follicular adenoma, and carcinoma, respectively. These results suggest that EGF, and ras and myc oncogenes or proto-oncogenes play a role in neoplastic lesions of the thyroid.
URI: http://hdl.handle.net/10069/15764
ISSN: 00016055
資料タイプ: Departmental Bulletin Paper
原稿種類: publisher
出現コレクション:Volume 34, No. 2-4

引用URI : http://hdl.handle.net/10069/15764

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