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Immunohistochemical Demonstration of myc Gene Product in Chick Embryo Aorta and Atherosclerotic Lesions in Chickens


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Title: Immunohistochemical Demonstration of myc Gene Product in Chick Embryo Aorta and Atherosclerotic Lesions in Chickens
Authors: Toda, Takayoshi
Issue Date: 9-Dec-1989
Citation: Acta medica Nagasakiensia. 1989, 34(2-4), p.173-176
Abstract: Expression of c-myc oncogene was immunohistochemically examined on aortas of chick embryo of 2-week gestational age, 2-week-old normal cockerels, 4-month-old normal roosters and 4-month-old cholesterl-fed roosters. Chick embryo showed moderate levels of expression of the c-myc oncogene product in the entire wall of the aortas. There was no significant expression of c-myc oncogenic protein in the thickened intima and the tunica media of the ascending aortic arch and its large branches of the cockerels and normal roosters. Cholesterol-fed roosters showed marked expression of c-myc oncogenic protein in the lipid-rich thickened intimal lesions of the ascending aortic arch and its large branches. These results suggest that c-myc oncogene has a role in proliferation and differentiation of aortic medial cells as well as development of atherosclerosis in chickens.
URI: http://hdl.handle.net/10069/15783
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 34, No. 2-4

Citable URI : http://hdl.handle.net/10069/15783

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