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Long-term Trend of Decreasing Frequency of Hepatitis B Virus Infection in Hepatitis, Cirrhosis, and hepatocellular carcinoma


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Title: Long-term Trend of Decreasing Frequency of Hepatitis B Virus Infection in Hepatitis, Cirrhosis, and hepatocellular carcinoma
Authors: Senba, Masachika / Nakamura, Tsuyoshi
Issue Date: 9-Dec-1989
Citation: Acta medica Nagasakiensia. 1989, 34(2-4), p.246-249
Abstract: Statistical and histopathological analysis was carried out to determine whether hepatitis B surface antigen with the necropsy diagnosis of hepatitis, cirrhosis, and hepatocellular carcinoma declined during 1964-1984. In this study, the liver specimens from 500 necropsy cases at Nagasaki University Hospital were used, and these materials were stained for hepatitis B surface antigen with immunoperoxidase method. For statistical calculations, we used Cochran's chi-squared test with one degree of freedom for linear trend for proportions. We investigated hepatitis B surface antigen positive rates for the three times periods, 1964-1970, 1971-1977, and 1978-1984, and those in the three diagnosis of hepatitis, cirrhosis, and hepatocellular carcinoma. The decreasing linear trend of hepatitis B surface antigen positivity with time was significant for hepatocellular carcinoma (and also for all three diagnosis combined ). This suggests that infection by hepatitis B virus in blood transfusion had fallen over the period in question.
URI: http://hdl.handle.net/10069/15795
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 34, No. 2-4

Citable URI : http://hdl.handle.net/10069/15795

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