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Atherosclerosis as a Proliferative Disease of Arterial Intimal Cells : An ultrastructural, immunohistochemical, and in situ hybridization study


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タイトル: Atherosclerosis as a Proliferative Disease of Arterial Intimal Cells : An ultrastructural, immunohistochemical, and in situ hybridization study
著者: Toda, Takayoshi / Nagamine, Masaru / Saeki, Norihisa / Takei, Hiroshi / Hokama, Seitetsu
発行日: 1989年12月 9日
引用: Acta medica Nagasakiensia. 1989, 34(2-4), p.250-256
抄録: Coronary arterise obtained from 35 autopsied cases were studied with the aid of electron microscopy, immunohistochemistry, and in situ hybridization. Smooth muscle cells were the main cellular components of the fibrocellular intimal thickening of the coronary artery. Atherosclerotic lesions were characterized by proliferation of smooth muscle cells as well as foam cells. Ultrastructural and immunohistochemical studies indicated that, foam cells originated from smooth muscle cells and macrophages. Immunohistochemistry showed low levels of expression of the myc oncogene product in the lesions of fibrocellular intimal thickening and increased expression of that in the early stage of the athlrosclerotic lesions. Both smooth muscle cell and macrophage were responsible for the expression of the myc oncogene. In situ hybridization demonstrated the presence of m-RNA of myc oncogene in the intimal cells of the uncomplicated atherosclerotic lesions.
URI: http://hdl.handle.net/10069/15796
ISSN: 00016055
資料タイプ: Departmental Bulletin Paper
原稿種類: publisher
出現コレクション:Volume 34, No. 2-4

引用URI : http://hdl.handle.net/10069/15796

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