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Atherosclerosis as a Proliferative Disease of Arterial Intimal Cells : An ultrastructural, immunohistochemical, and in situ hybridization study


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Title: Atherosclerosis as a Proliferative Disease of Arterial Intimal Cells : An ultrastructural, immunohistochemical, and in situ hybridization study
Authors: Toda, Takayoshi / Nagamine, Masaru / Saeki, Norihisa / Takei, Hiroshi / Hokama, Seitetsu
Issue Date: 9-Dec-1989
Citation: Acta medica Nagasakiensia. 1989, 34(2-4), p.250-256
Abstract: Coronary arterise obtained from 35 autopsied cases were studied with the aid of electron microscopy, immunohistochemistry, and in situ hybridization. Smooth muscle cells were the main cellular components of the fibrocellular intimal thickening of the coronary artery. Atherosclerotic lesions were characterized by proliferation of smooth muscle cells as well as foam cells. Ultrastructural and immunohistochemical studies indicated that, foam cells originated from smooth muscle cells and macrophages. Immunohistochemistry showed low levels of expression of the myc oncogene product in the lesions of fibrocellular intimal thickening and increased expression of that in the early stage of the athlrosclerotic lesions. Both smooth muscle cell and macrophage were responsible for the expression of the myc oncogene. In situ hybridization demonstrated the presence of m-RNA of myc oncogene in the intimal cells of the uncomplicated atherosclerotic lesions.
URI: http://hdl.handle.net/10069/15796
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 34, No. 2-4

Citable URI : http://hdl.handle.net/10069/15796

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