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Change in Circulating Immune Complex and Its Clinical Significance in Malignancy of Gastrointestinal Tract and Liver


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Title: Change in Circulating Immune Complex and Its Clinical Significance in Malignancy of Gastrointestinal Tract and Liver
Authors: Ooe, Hisakuni
Issue Date: 9-Dec-1989
Citation: Acta medica Nagasakiensia. 1989, 34(2-4), p.257-264
Abstract: Forty-seven patients with digestive tract malignancy and some benign diseases (cholelithiasis, duodenal ulcer) disease were subject to this study to clarify the changes in immunologic state in terms of complements. It has been often reported that circulating immune complex (CIC) was detected in infections disease. But CIC is also able to be detected in malignant disease without infection. The blood level of CIC changes regularly in perioperative period at the time of surgical resection of malignancy. In fact, preoperative value returned to normal in absolute curative operation for gastric cancer. Meanwhile, it was. variable during 7 days after operation in either benign or malignant diseases of gastrointestinal tract. The reason is that early period of surgery tends to be affected by operation insult, induced catabolic metabolism, nutritional defect and infection. After surgery to the liver, the changes in CIC were characteristic and CRA was suppressed coutinuously. Complement. protein C3, which is the most important component in CRA reaction, is generated in the liver. Therefore, it is considered that blood level of CRA is easily affected when hepatic surgery is made.
URI: http://hdl.handle.net/10069/15797
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 34, No. 2-4

Citable URI : http://hdl.handle.net/10069/15797

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