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Experimental study on lung preservationfunction of a 6 hour-preserved donor lung.

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Title: Experimental study on lung preservationfunction of a 6 hour-preserved donor lung.
Authors: Oka, Tadayuki
Issue Date: 9-Dec-1989
Citation: Acta medica Nagasakiensia. 1989, 34(2-4), p.272-282
Abstract: A donor lung was preserve during 6 hours by means of simple immersion with 4℃ modifield Euro-Collin's Solution and it was orthotopically transplanted. The function of transplanted lung was evaluated in terms of O2 intake by gas exchange and hemodynamic study following transplantation. The results were as follows 1) PaO2 values were significantly fallen immediately after transplantation. However, these were reverted to the normal on day 7.2) Intrapulmonary shunt rates did not significantly vary. In contrast, A-aDO2 values correlated with PaO2 values, reflecting uneveness of ventilation/perfusion and failure of diffusion in the early stage of postoperation. 3) Hemodynamically the mean pulmonary artery pressure and the pulmonary vascular resistance were increased immediately after transplantation but these returned on day 14. 4) On chest x-ray film, the infiltrative shadow on the transplanted lung was gradually reduced on day 7 and on day 14, the transplanted lung had become normal aeration on chest x-ray film. 5) In the early stage of postoperation, main histologic finding of a storaged donor lung was interstitial lung edema. In conclusion, it is clinically applicable that a 6 hour storaged lung by simple immersion with modified Euro-Collin's solution is well functioning and its function should be expected to be the same as that of nonstoraged one.
URI: http://hdl.handle.net/10069/15800
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 34, No. 2-4

Citable URI : http://hdl.handle.net/10069/15800

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