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Carcinoembryonic Antigen Production and Serum Levels in Esophageal Cancer

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Title: Carcinoembryonic Antigen Production and Serum Levels in Esophageal Cancer
Authors: Tomita, Masao / Ayabe, Hiroyoshi / Kawahara, Katsunobu / Hara, Shinsuke / Tagawa, Yutaka / Tochika, Hironobu
Issue Date: 14-Dec-1990
Citation: Acta medica Nagasakiensia. 1990, 35(1-4), p.39-42
Abstract: In the forty-four patients with esophageal cancer, serum carcinoembryonic antigen (CEA) levels were evaluated between pre- and postoperative periods in comparison with patients between positive and negative tissue CEA staining. Serum CEA levels were generally lower in patients with esophageal cancer and these showed less alteration in the postoperative period as compared with those in preoperative period. It is interest to emphasize that the survival following surgery in patients with negative tissue CEA staining in poor in this study. This study indicated that low serum CEA levels were shown in spite of local production of CEA in cancer cells, reflecting a blockage to release CEA to blood stream. It is believed that the variety of expression of cancer associated antigens is based on multiclonarity of cancer cells and/or alteration of expression of antigens with advances in tumor growth. However, it is dubious that CEA generated by carcinoma of the esophagus is indicative of aggressive behavior of the tumor and poor prognosis. Few reports are available in regard to expression of CEA antigen in patients with esophageal cancer. The pre-and postoperative CEA levels in patients with esophageal cancer remained unclear. The purpose of this study is to clarify clinical values of CEA measurement in patients with esophageal cancers.
URI: http://hdl.handle.net/10069/15809
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 35, No. 1-4

Citable URI : http://hdl.handle.net/10069/15809

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