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Morphological and Biochemical Evaluation of the Induction of Atherosclerosis in Japanese Quails


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Title: Morphological and Biochemical Evaluation of the Induction of Atherosclerosis in Japanese Quails
Authors: Oku, Hirosuke / Toda, Takayoshi / Hamada, Yushi / Kiyuna, Masaya / Chinen, Isao / Toyomoto, Mari / Shinjo, Akihisa
Issue Date: 14-Dec-1990
Citation: Acta medica Nagasakiensia. 1990, 35(1-4), p.81-87
Abstract: A total of 77 birds were divided into 7 groups which were fed the following diets : Group I, basal ; Group II, 5% corn oil (CO) + 0.5% cholesterol (CH) ; Group III, 5% CO + 2% CH; Group IV, 5% CO + 4% CH; Group V, 15% CO + 0.5% CH ; Group V I, 15% CO + 2% CH; Group VII, 15% CO + 4% CH. Significant increase of serum lipid, accumulation of lipid in the liver, and lipid-rich aortic lesions were produced in Groups IV, VI and VIII. However, hyperlipidemia correlated well with the extent of hepatic lipid accumulation and severity of aortic atherosclerosis in Group VI. Proliferating intimal cells showed positive reaction to antibodies for vimentin and alpha-1-antichymotrypsin implicating an important role of phenotypical transformation of intimal cells from the medial fibroblastic cells in the development of aortic atherosclerosis. These results suggest that Japanese quail is highly susceptible to atherosclerosis, and the optimal dietary level of cholesterol and corn oil is 2% and 15%, respectively to induce lipid-rich aortic lesions in Japanese quail.
URI: http://hdl.handle.net/10069/15818
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 35, No. 1-4

Citable URI : http://hdl.handle.net/10069/15818

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