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Cytoprotective roles of GSH, SOD and solcoseryl against ischemic damage and reperfusion injury to warm ischemic lung. Study of Canine warm ischemic lung.


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Title: Cytoprotective roles of GSH, SOD and solcoseryl against ischemic damage and reperfusion injury to warm ischemic lung. Study of Canine warm ischemic lung.
Authors: Taniguchi, Hideki / Kawahara, Katsunobu / Nakasone, Tomonori / Ikari, Hideki / Honjoh, Seiji / Hisano, Hiroshi / Takahashi, Takao / Kusano, Hiroyuki / Ayabe, Hiroyoshi / Tomita, Masao
Issue Date: 14-Dec-1990
Citation: Acta medica Nagasakiensia. 1990, 35(1-4), p.110-115
Abstract: This study was performed to clarify the roles of reduced glutathion (GSH), superoxide dismutase (SOD), and solcosaryl in ischemic damage and reperfusion injury to the warm ischemic lungs of experimental animals. Fifty-one warm ischemic canine lungs were made by hilar stripping and clamping of the left PA, PV and bronchus for 2-3 hours. In the Non-perfusion group, GSH (50mg/ kg, I. V.: Group II) and solcoseryl (50mg/kg, I. V.: Group III) were administered. In the perfusion group, Euro-Collins (E-C) solution (20ml/kg) was perfused (Group IV) and GSH (1mg/ml in E-C solution: Group V) and SOD (15mg/l in E-C solution : Group VI) were used for anti-oxidative drugs. The pulmonary arterial pressure and aortic pressure were measured and also blood gas analysis was made during the preischemic period , immediately after, one hour and 3 days after reperfusion. Small parts of pulmonary tissues were taken for pathological examination one hour and 3 days after reperfusion. Chest X-ray films were teken at 3 days after the operation. GSH, SOD, and solcoseryl effectively act as scavengers of active oxygen species (AOS) , especially in terms of oxygenation. In the group with anti-oxidative drugs, cytoprotective effects of the pathological and chest X-ray findings on ischemic damage and reperfusion injury were much more manifest rather than those in control groups.
URI: http://hdl.handle.net/10069/15823
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 35, No. 1-4

Citable URI : http://hdl.handle.net/10069/15823

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