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NAOSITE : Nagasaki University's Academic Output SITE > School of Medicine > Bulletin > Acta Medica Nagasakiensia > Volume 35, No. 1-4 >

Expression of c-myc, c-fos and CA19-9 in Human Non-Malignant and Malignant Gallbladder Tissues


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Title: Expression of c-myc, c-fos and CA19-9 in Human Non-Malignant and Malignant Gallbladder Tissues
Authors: Hamada, Yushi / Toda, Takayoshi / Kiyuna, Masaya / Muto, Yoshihiro / Miura, Myota / Sato, Nobutaka
Issue Date: 14-Dec-1990
Citation: Acta medica Nagasakiensia. 1990, 35(1-4), p.164-171
Abstract: Immunohistochemical study was performed on expressions of c-myc, c-fos and CA19-9 in gallbladder tissue with or without malignant lesions. A total of 81 tissues were divided into four groups including 47 carcinomas, 3 dysplasias, 17 metaplasias and 14 normal lesions. After these tissues were routinely fixed in 10% formalin solution and embedded in paraffin, 4 micrometer-thick sections were made and stained with hematoxylin-eosin to classify the type of lesions. Immunohistochemical stains were carried out for c-myc and c-fos oncoproteins, and CA19-9. The percentages of positive reaction for c-myc oncoprotein were 77%, 67%, 88% and 36%, those for c-fos oncoprotein were 83%, 66%, 35% and 7%, and those for CA19-9 were 85%, 100%, 88% and 71% in carcinoma, dysplasia, metaplasia and normal tissues, respectively. These results suggest that c-myc and c-fos oncogenes play some kind of roles in malignant transformation of the gallbladder tissues and that abnormal expression of CA19-9 is the sign of antigen reversion of carcinoma cells toward embryonic cells of the gallbladder tissue.
URI: http://hdl.handle.net/10069/15834
ISSN: 00016055
Type: Departmental Bulletin Paper
Text Version: publisher
Appears in Collections:Volume 35, No. 1-4

Citable URI : http://hdl.handle.net/10069/15834

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